| 目次 |
| 专 论 |
| 天然药物化学史话：甾体化合物 ------------------------------------------------------------------------------------------------------------------------(1251) 郭瑞霞，李力更，王于方，王 磊，张嫚丽，詹文红，史清文 |
| 化学成分 |
| 莛子藨地上部分1 个新的环烯醚 ------------------------------------------------------------------------------------------------------------------------(1265) 赵泽青，苏艳芳，黄 雄 |
| 列当中1 个新的苯乙醇苷化合物 ------------------------------------------------------------------------------------------------------------------------(1269) 王李俊，杨 琴，王 飞，朱 盼 |
| 四季青化学成分的研究 ------------------------------------------------------------------------------------------------------------------------(1272) 夏文绮，崔保松，李 帅 |
| 岩凤尾蕨化学成分的研究 ------------------------------------------------------------------------------------------------------------------------(1278) 李宛霏，邹 娟，李继新，张敬杰，潘炉台 |
| 芬戈莫德类似物的设计合成及抗肿瘤活性研究 ------------------------------------------------------------------------------------------------------------------------(1282) 陈 锴，马 宣，严 宁，解晓霞，姚 雷 |
| 桑菊饮抗炎活性成分筛选与单体验证 ------------------------------------------------------------------------------------------------------------------------(1289) 潘梓烨，常念伟，周梦鸽，段茜茜，李延美，姜 民，白 钢 |
| 药剂与工艺 |
| 星点设计-效应面法优化黄明胶-蜂蜜混合辅料膏方制备工艺 ------------------------------------------------------------------------------------------------------------------------(1297) 席啸虎，刘 霞，仝立国 |
| 白藜芦醇固体脂质纳米粒缓释凝胶骨架片的研制 ------------------------------------------------------------------------------------------------------------------------(1303) 吴先闯，郝海军，宋晓勇，张永州，刘瑜新，张红芹 |
| 藤黄酸长循环脂质体制备及药动学研究 ------------------------------------------------------------------------------------------------------------------------(1309) 王立英，刘雨萌，吴丽艳，赵成国，王艳珍，金元宝 |
| 原料勾兑在前列舒乐胶囊质量均一性控制中的应用 ------------------------------------------------------------------------------------------------------------------------(1315) 殷文静，魏惠珍，刘晟楠，金浩鑫，段奕倩，杨世林，朱益雷, 刘文霞，饶 毅 |
| 大黄结肠靶向微丸的制备及处方优化 ------------------------------------------------------------------------------------------------------------------------(1321) 张丹参，梅艳飞，宋晓敏，庄忠宝 |
| 苍术麸炒过程中5-羟甲基糠醛的转化机制研究 ------------------------------------------------------------------------------------------------------------------------(1327) 刘苗苗，陈祥胜，陈琪瑶，刘艳菊，付 伟，许安安，容艳芬 |
| 变波长RP-HPLC 法同时测定调经丸中12 种成分 ------------------------------------------------------------------------------------------------------------------------(1332) 陈雪梅，周 慧 |
| 药理与临床 |
| 三七总皂苷抑制大鼠全脑缺血后海马CA1区神经元凋亡及其机制研究 ------------------------------------------------------------------------------------------------------------------------(1337) 贺 旭，葛金文，邓长青，郭太平，潘爱华，李志远 |
| 南蛇藤提取物通过调控基质金属蛋白酶组及其抑制因子抑制人胃癌SGC-7901 细胞侵袭转移的研究 ------------------------------------------------------------------------------------------------------------------------(1345) 王海波，顾 昊，赵雪煜，冯 俊，钱亚云，杨 林，金 凤, 史有阳，陆松花，刘延庆 |
| 茜草炭不同提取物对急性血瘀模型大鼠的影响比较研究 ------------------------------------------------------------------------------------------------------------------------(1351) 王海丽，肖林焱，陈 毅，单鸣秋，张 丽，丁安伟 |
| 黄连水煎液中固体微粒对小檗碱在体肠吸收特性的影响研究 ------------------------------------------------------------------------------------------------------------------------(1357) 焦 放，侯子言，尹登科，杨 晔，桂双英 |
| 蜘蛛香提取物及总缬草素的抗焦虑活性研究 ------------------------------------------------------------------------------------------------------------------------(1361) 翟 欣，孔周扬，王素娟，蒋益萍，张 宏，郑承剑，秦路平 |
| 胃肠安丸合并蒿甲醚注射液治疗刚果（布）胃肠型疟疾临床观察 ------------------------------------------------------------------------------------------------------------------------(1366) 严苏纯，尹云泽，艾 乐，聂晓洁，朱雅楠，肖瑞颖 |
| 药材与资源 |
| 红花bZIP20 转录因子基因的克隆、表达分析及植物表达载体构建/a> ------------------------------------------------------------------------------------------------------------------------(1369) 官丽莉，崔 琪，韩怡来，顾天瑶，武云云，胡人阁，杜林娜, 李海燕，李校堃 |
| 基于1H-NMR 代谢组学技术研究“杀青”对连翘化学成分的影响 ------------------------------------------------------------------------------------------------------------------------(1375) 贾金萍，张福生，李震宇，马开庆，罗 辉，张立伟 |
| 川麦冬内生真菌分离和鉴定及抑菌活性初步研究 ------------------------------------------------------------------------------------------------------------------------(1382) 刘 雷，潘 峰，杨远兵，姜立春，邓 伶，邓 珍，刘 群 |
| 一测多评法测定决明子中橙黄决明素、大黄素、大黄酚和大黄素甲醚 ------------------------------------------------------------------------------------------------------------------------(1392) 梅国荣，刘 飞，王 福，卢俊宇，闫珂巍，谢亚菲，刘友平, 陈鸿平 |
| HPLC 法测定不同产地不同品种马勃药材中麦角甾醇 ------------------------------------------------------------------------------------------------------------------------(1397) 相聪坤，宿树兰，关胜江，黄怀鹏，王 巧，安福丽，陈迎春, 吴海燕，朱 珊 |
| HPLC-ELSD 法测定人参属药材不同部位中的20(R)-25-羟基-原人参三醇 ------------------------------------------------------------------------------------------------------------------------(1401) 胡婉琦，张 瑜，杨 宁，王 巍，崔炯谟，赵余庆 |
| ICP-MS 法测定金线莲中5 种重金属元素 ------------------------------------------------------------------------------------------------------------------------(1405) 沈廷明，刘知远，吴仲玉，陈 珏 |
| 综 述 |
| 麝香保心丸研究进展 ------------------------------------------------------------------------------------------------------------------------(1409) 刘 群，吕 超，张卫东，柳润辉 |
| 文冠果果壳化学成分与生物活性研究进展 ------------------------------------------------------------------------------------------------------------------------(1418) 杨春艳，杨军丽，哈 伟，师彦平 |
| 中药饮片灭菌的研究现状与思考 ------------------------------------------------------------------------------------------------------------------------(1425) 严 丹，袁 星，解达帅，胡美变，李明鉴，刘玉杰，吴纯洁 |
| 数据挖掘与复杂网络的融合及其在中医药领域应用 ------------------------------------------------------------------------------------------------------------------------(1430) 吕庆莉 |
| 药事管理 |
| 从发明专利视角分析山药开发现状 ------------------------------------------------------------------------------------------------------------------------(1437) 张一江，马运运，孙志一，刘海波，彭 勇 |
| Main Contents |
| Special Topic |
| Historical story on natural medicinal chemistry: Steroids ------------------------------------------------------------------------------------------------------------------------(1251) GUO Rui-xia, LI Li-geng, WANG Yu-fang, WANG Lei, ZHANG Man-li, ZHAN Wen-hong, SHI Qing-wen |
| Chemical Constituents |
| One new iridoid from aerial parts of Triosteum pinnatifidum ------------------------------------------------------------------------------------------------------------------------(1265) ZHAO Ze-qing, SU Yan-fang, HUANG Xiong |
| A new phenethyl alcohol glycoside from Orobanche coerulescens ------------------------------------------------------------------------------------------------------------------------(1269) WANG Li-jun, YANG Qin, WANG Fei, ZHU Pan |
| Chemical constituents from leaves of Ilex chinensi ------------------------------------------------------------------------------------------------------------------------(1272) XIA Wen-qi, CUI Bao-song, LI Shuai |
| Chemical constituents from Pteris deltodon ------------------------------------------------------------------------------------------------------------------------(1278) LI Wan-fei, ZOU Juan, LI Ji-xin, ZHANG Jing-jie, PAN Lu-tai |
| Design and synthesis of fingolimod analogues as well as evaluation on their antitumor activity ------------------------------------------------------------------------------------------------------------------------(1282) CHEN Kai, MA Xuan, YAN Ning, XIE Xiao-xia, YAO Lei |
| Screening of activity components with anti-inflammation in Sang Ju Yin and verification of monomer ------------------------------------------------------------------------------------------------------------------------(1289) PAN Zi-ye, CHANG Nian-wei, ZHOU Meng-ge, DUAN Xi-xi, LI Yan-mei, JIANG Min, BAI Gang |
| Pharmaceutics and Technology |
| Optimization of processing technology for cream with mixed accessories of oxhide gelatin and honey by central composite design-response surface methodology ------------------------------------------------------------------------------------------------------------------------(1297) XI Xiao-hu, LIU Xia, TONG Li-guo |
| Preparation of hydrogel matrix sustained-release tablets of resveratrol-solid lipid
nanoparticles ------------------------------------------------------------------------------------------------------------------------(1303) WU Xian-chuang, HAO Hai-jun, SONG Xiao-yong, ZHANG Yong-zhou, LIU Yu-xin, ZHANG Hong-qin |
| Preparation and pharmacokinetics of gambogic acid long-circulating liposomes ------------------------------------------------------------------------------------------------------------------------(1309) WANG Li-ying, LIU Yu-meng, WU Li-yan, ZHAO Cheng-guo, WANG Yanzhen, JIN Yuan-bao |
| Application of blending raw materials in quality consistency control of Qianlie Shule Capsule ------------------------------------------------------------------------------------------------------------------------(1315) YIN Wen-jing, WEI Hui-zhen, LIU Sheng-nan, JIN Hao-xin, DUAN Yi-qian, YANG Shi-lin, ZHU Yi-lei, LIU Wen-xia, RAO Yi |
| Preparation and formulation optimization of Rheum Colon Targeted Pellets ------------------------------------------------------------------------------------------------------------------------(1321) ZHANG Dan-shen, MEI Yan-fei, SONG Xiao-min, ZHUANG Zhong-bao |
| Conversion mechanism of 5-hydroxymethylfurfural in process of bran-fried Atractylodes lancea ------------------------------------------------------------------------------------------------------------------------(1327) LIU Miao-miao, CHEN Xiang-sheng, CHEN Qi-yao, LIU Yan-ju, FU Wei, XU An-an, RONG Yan-fen |
| Simultaneous determination of 12 chemical components in Tiaojing Pills by RP-HPLC under variable wavelengths ------------------------------------------------------------------------------------------------------------------------(1332) CHEN Xue-mei, ZHOU Hui |
| Pharmacological Studies and Clinical Observations |
| Inhibition and machanisms of total saponins from Panax notoginseng on apoptosis of hippocampal CA1 subfield neurons of rats following global cerebral ischemia ------------------------------------------------------------------------------------------------------------------------(1337) HE Xu, GE Jin-wen, DENG Chang-qing, GUO Tai-ping, PAN Ai-hua, LI Zhi-yuan |
| Research on effect of Celastrus orbiculatus extract on inhibiting invasion and metastasis of human gastric cancer SGC-7901 cells by mediating matrix metalloproteinases group and their inhibitors ------------------------------------------------------------------------------------------------------------------------(1345) WANG Hai-bo, GU Hao, ZHAO Xue-yu, FENG Jun, QIAN Ya-yun, YANG Lin, JIN Feng, SHI You-yang, LU Song-hua, LIU Yan-qing |
| Comparative study on effect of different extracts from carbonized Rubiae Radix et Rhizoma in acute blood stasis model of rats ------------------------------------------------------------------------------------------------------------------------(1351) WANG Hai-li, XIAO Lin-yan, CHEN Yi, SHAN Ming-qiu, ZHANG Li, DING An-wei |
| Effect of solid particles in coptis decoction on intestinal absorption of berberine in situ ------------------------------------------------------------------------------------------------------------------------(1357) JIAO Fang, HOU Zi-yan, YIN Deng-ke, YANG Ye, GUI Shuang-ying |
| Study on anti-anxiety activity of extract and total valepotriate in Valerianae Rhizoma ------------------------------------------------------------------------------------------------------------------------(1361) ZHAI Xin, KONG Zhou-yang, WANG Su-juan, JIANG Yi-ping, ZHANG Hong, ZHENG Cheng-jian, QIN Lu-ping |
| Treatment of malaria (gastrointestinal type) by Wei Chang An Pills combined with Artemether Injection in the Republic of Congo ------------------------------------------------------------------------------------------------------------------------(1366) YAN Su-chun, YIN Yun-ze, AI Le, NIE Xiao-jie, ZHU Ya-nan, XIAO Rui-ying |
| Medicinal Materials |
| Cloning and expression analysis of CtbZIP20 transcription factor gene from Carthamus tinctorius and construction of plant expression vector ------------------------------------------------------------------------------------------------------------------------(1369) GUAN Li-li, CUI Qi, HAN Yi-lai, GU Tian-yao, WU Yun-yun, HU Ren-ge, DU Lin-na, LI Hai-yan, LI Xiao-kun |
| Effect of deactivation of enzymes on chemical composition of Forsythiae Fructus using 1H-NMR-based metabolomics approach ------------------------------------------------------------------------------------------------------------------------(1375) JIA Jin-ping, ZHANG Fu-sheng, LI Zhen-yu, MA Kai-qing, LUO Hui, ZHANG Li-wei |
| Isolation and identification of fungal endophytes from Ophiopogon japonicus and their antimicrobial activities ------------------------------------------------------------------------------------------------------------------------(1382) LIU Lei, PAN Feng, YANG Yuan-bing, JIANG Li-chun, DENG Ling, DENG Zhen, LIU Qun |
| Determination of constituents of aurantio-obtusin, emodin, rhubarb, and physcion in Cassiae Semen by multi-components by single mark ------------------------------------------------------------------------------------------------------------------------(1392) MEI Guo-rong, LIU Fei, WANG Fu, LU Jun-yu, YAN Ke-wei, XIE Ya-fei, LIU You-ping, CHEN Hong-ping |
| Determination of ergosterol in Lasiosphaera Seu Calvatia in various species from different habitats by HPLC ------------------------------------------------------------------------------------------------------------------------(1397) XIANG Cong-kun, SU Shu-lan, GUAN Sheng-jiang, HUANG Huai-peng，WANG Qiao, AN Fu-li, CHEN Ying-chun, WU Hai-yan, ZHU Shan |
| Determination of 20(R)-25-OH-PPT in different parts of species in Panax Linn. by HPLC-ELSD methods ------------------------------------------------------------------------------------------------------------------------(1401) HU Wan-qi, ZHANG Yu, YANG Ning, WANG Wei, CUI Jiong-mo, ZHAO Yu-qing |
| Determination of five kinds of heavy metals in Anoectochilus roxburghii by ICP-MS ------------------------------------------------------------------------------------------------------------------------(1405) SHEN Ting-ming，LIU Zhi-yuan，WU Zhong-yu，CHEN Jue |
| Review |
| Advance in modern studies on Shexiang Baoxin Pill ------------------------------------------------------------------------------------------------------------------------(1409) LIU Qun, LV Chao, ZHANG Wei-dong, LIU Run-hui |
| Advances in studies on chemical constituents from husks of Xanthoceras sorbifolia and their biological activities ------------------------------------------------------------------------------------------------------------------------(1418) YANG Chun-yan, YANG Jun-li, HA Wei, SHI Yan-ping |
| Research status and thoughts on sterilization of Chinese herbal medicine pieces ------------------------------------------------------------------------------------------------------------------------(1425) YAN Dan, YUAN Xing, XIE Da-shuai, HU Mei-bian, LI Ming-jian, LIU Yu-jie, WU Chun-jie |
| Integration of data mining and complex networks and its application in traditional Chinese medicine ------------------------------------------------------------------------------------------------------------------------(1430) LV Qing-li |
| Pharmacy Administration |
| Development analysis of Dioscoreae Rhizoma in perspective of invention patent ------------------------------------------------------------------------------------------------------------------------(1437) ZHANG Yi-jiang, MA Yun-yun, SUN Zhi-yi, LIU Hai-bo, PENG Yong |