目的 以补阳还五汤为模型药方，探索有效成分群（部位）溶度参数的变化规律。方法 用均匀设计、星点设计安排实验方案，用改良反相气相色谱法（IGC）测定溶度参数值，用SPSS软件拟合曲线方程。结果 得出有效成分黄芪甲苷（X₁）、阿魏酸（X₂）、芍药苷（X₃）、川芎嗪（X₄）的溶度参数的递推方程为Y=-69.016+435.277 X₁X₂+336.966 X₂X₄+487.702 X₃X₄－54.575 X₁²－59.696 X₂X₃（r=1.000，P<0.01）；有效部位总苷类（X₁）、总生物碱（X₂）、总多糖（X₃）的溶度参数的递推方程为Y=21.822+10.562 X₁+51.512 X₂－37.078 X₃+163.820 X₁X₂－155.569 X₁X₃－506.750 X₂X₃－9.385 X₁²+19.864 X₂²+413.446 X₃²（r=0.866，P<0.01）。结论 建立的递推规律方程揭露了中药单一成分与复杂体系间的必然联系及递推规律，为中药复方溶出规律研究奠定了基础。

Objective To take Buyanghuanwu Decoction as a model for exploring the variable rule of solubility parameters for the effective components group (fraction). Methods To arrange the experiment design by uniform design and central composite plan, to determine the solubility parameter values with the modified inverse gas chromatography (IGC), and to fit the curve equation using SPSS software. Results The recursive equation for the major active component including astragaloside (X₁), ferulic acid (X₂), paeoniflorin (X₃), and ligustrazine (X₄) was Y = -69.016 + 435.277 X₁X₂ + 336.966 X₂X₄ + 487.702 X₃X₄－54.575 X₁²－59.696 X₂X₃ (r = 1.000, P < 0.01); The recursive equation for the active part including total glycosides (X₁), and total alkaloids (X₂), total polysaccharide (X₃) was Y = 21.822 + 10.562 X₁ + 51.512 X₂－37.078 X₃ + 163.820 X₁X₂－155.569 X₁X₃－506.750 X₂X₃－9.385 X₁² + 19.864 X₂² + 413.446 X₃² (r = 0.866, P < 0.01). Conclusion The recursive rule equation has revealed the inevitable connection between the single component of Chinese materia medica and complex system, which could lay the foundation for the further research on the solubility rule of traditional Chinese medicine compound.

国家自然科学基金资助项目（30901971，81270055）；湖南省自然科学基金项目（14JJ2110，14JJ7061）