表没食子儿茶素没食子酸酯（epigallocatechin-3-gallate，EGCG）是绿茶的主要成分之一。研究表明，EGCG具有抗氧化、预防癌症、抗炎、抗菌等作用。近年来，心脑血管疾病已成为当今世界影响人类健康最显著的疾病，而目前仅有少数神经保护药物能够用于治疗缺血性中风。很多基础研究证实，EGCG对于心脑血管缺血再灌注损伤具有独特的疗效，主要体现在调节氧化应激、抗细胞凋亡、抗炎、激活腺苷受体、降低血脑屏障的通透性及降低基质金属蛋白酶-9（MMP-9）表达等方面。针对EGCG对心脑血管缺血再灌注损伤保护作用机制进行综述，以期能为有效治疗心脑血管缺血性疾病药物的开发提供参考。

Epigallocatechin-3-gallate (EGCG) is one of the major components in green tea. It has been studied that EGCG possesses anti-oxidative, anticancer, anti-inflammatory, and antibacterial effects. In recent years, cardiovascular and cerebrovascular diseases have been exerting the most significant impact on human health, however, only a few neuroprotective drugs can be used in the treatment of ischemic stroke. Many studies reveal that EGCG has unique therapeutic effect on cardiovascular and cerebrovascular ischemia-reperfusion injury. EGCG mainly exerts its protective effects by regulating oxidative stress, anti-apopsis, anti-inflammation, activation of adenosine receptors, lowering blood-brain barrier permeability, and reducing matrix metalloproteinase-9 expression. This review focuses on the mechanism of action of EGCG in the treatment of cardiovascular and cerebrovascular ischemia-reperfusion injury, in order to provide rationale or the development of effective drugs for ischemic cardiovascular and cerebrovascular diseases.

国家自然科学基金资助项目（81274124）