Brusatol: A potential anti-tumor quassinoid from Brucea javanica
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
摘要:
Abstract:
Brusatol, a triterpene lactone compound mainly from Brucea javanica, sensitizes a broad spectrum of cancer cells. It is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. In this review, we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in vivo. This review also covers pharmacokinetics studies, modification of dosages forms of brusatol. Increasing evidences have validated the value of brusatol as a chemotherapeutic agent in cancers, which may contribute to drug development and clinical application.
关键词:
Keywords:
Project Supported:
This research work was supported by National Nature Science Foundation of China (81872767).
