Plantago (Plantaginaceae family) exhibits remarkable diversity with over 200 species. These plants areclosely associated with traditional medicine worldwide, particularly as a wound healing therapy.Recent research has revealed phytoconstituents in various Plantago species, including flavonoids, alkaloids, terpenoids, phenolic acid derivatives, iridoid glycosides, fatty acids, and polysaccharides. Despitethe advanced ongoing research on Plantago extracts, there is still a gap in the evaluation of their potentialas an effective topical product for chronic wounds and in the way phytoconstituents contribute to theoverall effect in a single comprehensive systematic review. Therefore, this review aims to explore thewound healing capabilities of Plantago and its phytoconstituents, as well as elucidate their mechanismsof action. Our analysis emphasizes the significant wound healing potential in 25 Plantago species, notablyPlantago major, Plantago lanceolata, Plantago australis, Plantago asiatica, and Plantago ovata. These plantspecies contain a diverse array of 57 phytoconstituents that collectively contribute to these activities. In conclusion, this review confirms the huge potential of Plantago genus as a topical wound healing agent.The healing mechanisms cover a wide array of effects such as anti-bacterial activity, anti-apoptosis, stimulation of collagen synthesis and deposition, promotion of angiogenesis, suppression of inflammatory response, inhibition of cyclooxygenase, inhibition of MAPKs phosphorylation, and enhancement of endogenous antioxidant enzyme activity. A study on the network pharmacology of such potential is worth investigating as further research.
关键词:
绿原酸;植物化学成分;狭叶车前;大车前;车前草属;传统医学;伤口愈合
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Project Supported:
This review has been part of research funded by BRIN through the RIIM project scheme (No. 34/IV/KS/06/2022). We express our gratitude to Universitas Gadjah Mada for the ease of accessing academic article publications.
Triana Hertiani a,?, Muhammad Khafi b, Latifa Amalia b, c, Muhamad Bayu Irawan b. Plantago mechanisms for enhanced wound healing: A review on bioactive phytoconstituents[J]. Chinese Herbal Medicines (CHM),2026,18(3):662-683
