Chronic respiratory diseases (CRDs) are multifactorial disorders driven by dysregulated inflammation,oxidative stress, and tissue remodeling. Conventional single-target therapies are insufficient to halt disease progression, underscoring the demand for alternative therapeutic approaches. Natural products,including bioactive compounds, herbal extracts, and traditional Chinese medicine (TCM) formulas, arecharacterized by their inherent multi-target properties and represent a promising intervention strategyfor CRDs. This perspective emphasizes natural products as network modulators that can simultaneouslyregulate multiple signaling pathways. The integration of systems biology, network pharmacology, andartificial intelligence (AI) is crucial for deciphering their polypharmacological mechanisms. The clinicaltranslation of natural products is anticipated to benefit from the implementation of several key strategies,including multi-omics integration, AI, targeted delivery, and blockchain-based quality control. By shiftingfrom a reductionist to a network-centric view, natural products can fulfill their potential as nextgeneration therapeutics for CRDs.
关键词:
慢性呼吸系统疾病;临床转化;多通路靶向;天然产物;网络调控;中药
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This work was supported by National Natural Science Founda tion of China (Nos. 82574667, 81873071, 22407028), China; GDAS‘ Project of Science and Technology Development (No. 2024GDASZH-2024010102), China; Young Talent Project of GDAS(No. 2024GDASQNRC-0313), China. We are grateful for the support of this work by ‘‘Paragon Scholar Program” at The First Affiliated Hospital of Guangdong Pharmaceutical University.
Siqi Lin a, b,, Lili Li c,, Shiqing Zhuo a, b, Liang Yu a, b, Yu Huang a, b, Xiaofei Chen d,?, Huihui Ti a, b,e,?. Multi-pathway targeting by natural products in chronic respiratory diseases: Opportunities, challenges, and future perspectives[J]. Chinese Herbal Medicines (CHM),2026,18(3):638-642
