As the only naturally occurring stable derivative of L-ascorbic acid (AA; vitamin C), 2-O-b-Dglucopyranosyl-L-ascorbic acid (AA-2bG) is hydrolyzed in vivo to release active AA. AA-2bG exhibits strong antioxidant and antiphotoaging effects comparable to those of AA, and it plays a key role in maintaining organismal health. Owing to its superior stability and bioavailability, AA-2bG is considered as a promising, longer-lasting natural alternative to conventional vitamin C. It was first identified and is particularly abundant in Lycii Fructus (Gouqizi in Chinese) but has been detected in several crop plants. This review offers a comprehensive overview of recent advances in AA-2bG research, covering key aspects including discovery, structure, natural sources, extraction and detection methods, chemical and in vitro enzymatic synthesis, biosynthetic pathways, as well as applications in health care, skin care, and functional foods. Additionally, we highlight strategies for leveraging plant resources and enhancing AA-2bG biosynthesis, which are expected to accelerate future research and support the sustainable development and utilization of AA-2bG and other high-value natural products.
关键词:
2-O-β-D-葡萄吡喃糖基-L-抗坏血酸;抗坏血酸衍生物;枸杞;天然产物;维生素C
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This research was funded by the National Key Research and Development Program (Nos. 2023YFC3504104 and 2024YFD2100700); the Fundamental Research Funds for the Central public welfare research institutes (No. ZZ13-YQ-101); Scientific and technological innovation project of China Academy of Chinese Medical Sciences (No. CI2023E002-Y-28).
Mengyue Wang a,, Haotian Wu a,, Li Xiang a, Ranran Gao a, Qinggang Yin a, Yang Chu a, Lan Wu a, Yanyan Su b, Gangqiang Dong b,?, Yuhua Shi a,?. Natural novel vitamin C derivative, 2-O-b-D-glucopyranosyl-L-ascorbic acid: Resources, biosynthesis, and applications[J]. Chinese Herbal Medicines (CHM),2026,18(1):77-88
