Meroterpenoids are secondary metabolites partially derived from the terpenoid biosynthetic pathway, and are widely distributed in plants, animals, and fungi. These natural products possess complex backbone structures and diverse bioactivities. Ganoderma meroterpenoids (GMs) form a distinct group of meroterpenoids were characterized by the presence of 1,2,4-trisubstituted phenyl and polyunsaturated terpene moieties. Various Ganoderma species have been extensively studied, leading to the discovery of several structurally unique meroterpenoids with significant pharmacological activities. After the first isolation and identification of GMs in 2 000, over 300 compounds from 14 species have been characterized for their structures and biological activities. The structures and activities of some GMs from different Ganoderma species vary greatly, probably due to significant differences in the genome and transcriptome of different Ganoderma species. We predicted the related enzymes based on the reported Ganoderma genome and proposed the biosynthetic pathway related to GMs. The results presented in this review provide a scientific foundation for the comprehensive exploration and utilization of diverse Ganoderma resources.
关键词:
生物活性;生物合成;灵芝种类;杂萜;结构多样性
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Project Supported:
This research was funded by the National Natural Science Foundation of China (No. U22A20369, 32370069 and 31800031) and the Natural Science Foundation of Heilongjiang Province of China (No. LH2023C035).
Shuang Peng a,, Jianzhao Qi a, b,, Chao Lin b, Zhichao Xu a, b, Zhenhao Li c,?, Chengwei Liu a,?. From natural laboratory to drug discovery: Chemical structures, bioactivities, and biosynthesis of meroterpenoids from Ganoderma species[J]. Chinese Herbal Medicines (CHM),2026,18(1):29-44
