The discovery and characterization of molecular targets from traditional Chinese medicine (TCM) represents a paradigm shift in contemporary drug development. This approach systematically bridges empirical TCM knowledge with modern pharmacological principles, establishing a robust framework for rational drug design. Through integrative systems-chemical biology approaches, we can now mechanistically elucidate the therapeutic basis of TCM’s bioactive properties, facilitating the accelerated identification of both novel molecular targets and conserved pharmacological pathways. This multidisciplinary strategy significantly enhances drug development efficiency while advancing therapeutic innovation to address critical unmet medical needs. With the rapid advancement of next-generation target deconvolution technologies and AI-driven computational platforms, TCM is poised to make increasingly substantial contributions to modern pharmacotherapy.
关键词:
靶点鉴定;化学生物学;系统生物学;药性;药效
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This work was supported by the National Key R&D Program of China (No. 2024YFC3506600), the National Natural Science Foundation of China (Nos. 82474198 and 82274184).
