Acute lung injury (ALI) and its more severe manifestation, acute respiratory distress syndrome (ARDS), continue to pose a substantial challenge for contemporary society. Having been linked to the processes of injury and inflammation, NLRP3 inflammasome is activated by various stimuli, including inhaled allergens, pathogens, and environmental pollutants, subsequently contributing to the dysfunction of the innate immune system. Understanding how the innate immune NLRP3 inflammasome is altered during ALI may facilitate the identification of new therapeutic targets. To further enrich the role of NLRP3 inflammasome in treating ALI with traditional Chinese Medicine (TCM), this review aims to thoroughly summarize the latest scientific research achievements on the effects of NLRP3 inflammasome in ALI, and the existing underlying therapeutic targets from TCM and natural products.
关键词:
急性肺损伤;先天免疫;天然产物;NLRP3炎性小体;中药
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This work was supported by the Natural Science Foundation of Tianjin (No. S24ZS03048), the Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (No. 22HHZYSS00011),
Yiman?Liu?, Junyu?Meng?, Jia?Liu, Fan?Zhang, Chen?An, Jian?Yang *. NLRP3 inflammasome in acute lung injury: Cumulative evidence for traditional Chinese medicine and natural products[J]. Chinese Herbal Medicines (CHM),2025,17(4):703-719
