Coronary atherosclerotic heart disease is a major cardiovascular condition driven by atherosclerosis, distinguished by chronic inflammation and dysregulated lipid metabolism. The gut microbiota plays an essential role in human health and disease, with research indicating a strong association between gut microbial metabolism and the development and progression of coronary heart disease. This article provides a review of the relationship between gut microbiota and coronary heart disease, as well as the mechanisms by which traditional Chinese medicine regulates digestive tract microbiota to treat coronary heart disease, which systematically explains how the gut microbiota, through metabolic products and immune regulation, contributes to the occurrence and progression of coronary heart disease, and summarizes recent advances in research on traditional Chinese medicine’s regulation of gut microbiota for treating coronary heart disease. It aims to provide further reference and insights for exploring the relationship between gut microbiota and coronary heart disease, as well as traditional Chinese medicine approaches for treating coronary heart disease.
关键词:
冠心病;肠道菌群;作用机制;治疗;中药
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This study was supported by National Nature Science Foundation of China (No. 82374367), Jiangxi Provincial Natural Science Foundation (No. 20242BAB26163, 20232BAB206144), Jiangxi Provincial Traditional Chinese Medicine Research Project (No. 2023A0104), Jiangxi Province Key Laboratory of Traditional Chinese Medicine for Cardiovascular Diseases (No. 20242BCC32096), NATCM’s Project of High-level Construction of Key TCM Disciplines (No. zyyzdxk-2023113), Project of Key Discipline Construction Fund of Jiangxi University of Chinese Medicine (No. 2023jzzdxk032), Science and Technology Innovation Team Development Program of Jiangxi University of Chinese Medicine (No. CXTD22011), National Traditional Chinese Medicine Inheritance and Innovation Center Construction Project, Jiangxi Graduate student Innovation Special Fund Project (No. YC2023-S782). Thanks for the copyright support from Figdraw Software.
Qiwen Lu a, Sang Luo a, Chengyan Guan a, Hao Zhang a, Haoyue Jia a, Qiang Wan b,?. Research progress of regulating intestinal flora by traditional Chinese medicine in treating coronary heart disease[J]. Chinese Herbal Medicines (CHM),2025,17(3):464-472
