Natural polyphenols as novel interventions for aging and age-related diseases: Exploring efficacy, mechanisms of action and implications for future research
Natural polyphenols are a group of components widely found in traditional Chinese medicines and have been demonstrated to delay or prevent the development of aging and age-related diseases in recent years. As far as we know, the studies of natural polyphenols in aging and aging-related diseases have never been extensively reviewed. In the present paper, we reviewed recent advances of natural polyphenols in aging and common age-related diseases and the current technological methods to improve the bioavailability of natural polyphenols. The results showed that natural polyphenols have the potential to prevent or treat aging and common age-related diseases through multiple mechanisms. Nanotechnology, structural modifications, and matrix processing could provide strong technical support for the development of natural polyphenols to prevent or treat aging and age-related diseases. In conclusion, natural polyphenols have important potential in the prevention and treatment of aging and agerelated diseases.
关键词:
衰老;癌症;心血管疾病;天然多酚;神经退行性疾病
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Project Supported:
This work was supported by National Natural Science Foundation of China (No. 82174076), the Construction Project of Liaoning Provincial Key Laboratory, China (No. 2022JH13/10200026), the Fundamental Research Funds for the Central Universities (No. N2220002) and 111 Project (No. B16009), Natural Science Foundation of Top Talent of SZTU (No. GDRC202404), and Shenzhen Medical Research Fund (No. D2402007).
Wenze Wu a,, Yan Mi a,, Qingqi Meng a, Ning Li b, Wei Li c, Pu Wang d,*, Yue Hou a,*. Natural polyphenols as novel interventions for aging and age-related diseases: Exploring efficacy, mechanisms of action and implications for future research[J]. Chinese Herbal Medicines (CHM),2025,17(2):279-291
