Post-traumatic stress disorder (PTSD) is a relatively common but complex mental illness with a range of diverse risk factors. Typical symptoms include the re-experience or avoidance of traumatic events, cognitive impairment, and hypervigilance. While the exact pathogenesis of PTSD is unclear, many studies indicate that epigenetic regulation plays a key role in its development. Specifically, numerous studies have indicated that the levels of histone acetylation and methylation, DNA methylation, and noncoding RNA are altered in PTSD patients. Further to this, natural products have been found to achieve epigenetic regulation of PTSD by regulating the expression of epigenetic enzymes, long noncoding RNA (lncRNA), and miRNA, thereby playing a role in improving PTSD symptoms. To date, however, no epigenetic regulation related drugs have been used in the treatment of PTSD. Furthermore, while natural products that can epigenetically regulate PTSD have received increasing levels of attention, there have not yet been any systematic reports on the topic. Here, we summarized the roles and mechanisms of natural products in the epigenetic regulation of PTSD, providing a novel and unique perspective that will help to guide the development and application of new PTSD treatments.
关键词:
DNA甲基化;表观遗传调控;组蛋白修饰;天然产物;非编码RNA;创伤后应激障碍
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This research was supported by the Project of National Natural Science Foundation of China (No. 82074041, 82004051, 81803508), Funded by China Postdoctoral Science Foundation (No. 2020M670674), the Scientific Research Fund from Liaoning Education Department (No. 2020LQN02, LJKZ0923, LJKQZ2021029), Natural Science Foundation of Liaoning Province (No. 2021-MS-216), Fund for distinguished young scholars of Shenyang Pharmaceutical University (No. ZQ202202), Fund for outstanding young scholars of Shenyang Pharmaceutical University (No. YQ202103) and rolling funding of young and middle-aged teachers’ career development project of Shenyang Pharmaceutical University.
Meijing Xu, Minghui Cui, Yu Wang, Boru Li, Lijin Feng, Hang Xing *, Kuo Zhang *. Therapeutic potentials of natural products for post-traumatic stress disorder: A focus on epigenetics[J]. Chinese Herbal Medicines (CHM),2025,17(2):203-219
