Advances in phytochemistry, ananlysis methods and pharmacology of Eleutherococcus trifoliatus: A promising medicinal and edible resource with development value
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摘要:
三叶五加（Eleutherococcus trifoliatus (L.) S. Y. Hu）在中国被称为白簕或簕菜，是一种在民间传统中广泛使用的药食两用植物。作为传统中草药，三叶五加具有清热解毒、祛风除湿、活血化瘀、镇痛、止咳平喘的功效。研究发现其所含化学成分较多，包括二萜皂苷、三萜皂苷、苯丙素、黄酮、木脂素、咖啡酸单宁、甾类、挥发油等，其中黄酮、皂苷和咖啡酸单宁是最具活性的成分。体外和体内药理实验表明，三叶五加具有抗炎、降糖、抗癌、抗氧化、抗菌、抗过敏、抗疲劳、镇痛和止血作用。本文对三叶五加在植物化学、分析方法和药理学方面的研究进展进行综述。
Abstract:
Eleutherococcus trifoliatus (Araliaceae) is called Baile or Lecai in China. E. trifoliatus is a medicinal and edible plant widely used in folk traditions. As a TCM, the dried herb of this species can remove damp heat and detoxicity, cure rheumatism, remove blood stasis, relieve pain, and alleviate cough and asthma symptoms. Many chemical compounds have been reported including diterpenoids, triterpenoids, phenylpropanoids, flavonoids, lignans, caffeoyl quinic acids, steroids, essential oils, etc., in which flavonoids, saponins, and caffeoyl quinic acids are the most bioactive components. In vitro and in vivo pharmacological experiments demonstrated that E. trifoliatus has anti-inflammatory, hypoglycemic, anticancer, antioxidant, antibacterial, anti-hyperalgesic, anti-fatigue, analgesic, and hemostatic effects. Here we reviewed E. trifoliatus in phytochemistry, analysis methods, and pharmacology.
关键词:
五加科;分析方法;抗炎;三叶五加;药理学;植物化学;毒性
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Project Supported:
This work was supported by Natural Science Foundation of Hunan Province (No. 2023JJ60213 and 2024JJ7357); The Key Discipline of Biological Engineering in the Fourteenth Five-year Plan of Hunan University of Chinese Medicine [XiaoXingFaGuiZi-2023-No.2]; Hunan Provincial Innovation Foundation for Postgraduate (No. QL20220186); Scientific Research Program of Hunan Provincial Education Department (No. 23C0155); The Key Discipline of Pharmacy in Hunan Province.
Maofang Lu a,, Bin Wang a,, Ling Dai b, Jian Wu c, Jiao Luo a, Changsoo Yook d, Xiangqian Liu a,*. Advances in phytochemistry, ananlysis methods and pharmacology of Eleutherococcus trifoliatus: A promising medicinal and edible resource with development value[J]. Chinese Herbal Medicines (CHM),2025,17(1):19-30
