Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms
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摘要:
：心脑血管疾病是由心脏缺陷和血管疾病引起的一种循环系统疾病，是影响全球公共卫生的主要非传染性疾病之一。随着经济水平的提高和人们生活方式的改变，心脑血管疾病的患病率不断上升。人参(Panax ginseng C. A. Mey.)因其滋补作用而被广泛用于传统疾病中。人参皂苷Rb1 (G-Rb1)是从人参中提取的最丰富的且具有多种药理作用的活性成分，已被证明通过抗氧化、抗炎、调节血管舒张、减少血小板粘附、影响钙离子通道、改善脂质分布、参与葡萄糖代谢等多种机制对心血管系统具有潜在的益处。本文针对G-Rb1对动脉粥样硬化、高血压、冠心病、缺血性脑卒中、眼周微血管视网膜病变等心脑血管疾病的保护作用及其可能机制进行综述。最后，作者回顾并报道了G-Rb1改善心脑血管疾病的体内和体外实验结果，并强调了其有效性、安全性和局限性。
Abstract:
Cardiovascular and cerebrovascular diseases (CCVDs), which are circulatory system diseases caused by heart defects and vascular diseases, are the major noncommunicable diseases affecting global public health. With the improvement of economic level and the change of human lifestyle, the prevalence of CCVDs continues to increase. Ginseng (Panax ginseng C. A. Mey.) was widely used in traditional diseases due to its supposed tonic properties. Ginsenoside Rb1 (G-Rb1) is the most abundant active ingredient with multiple pharmacological effects extracted from ginseng, which has been shown to have potential benefits on the cardiovascular system through a variety of mechanisms, including anti-oxidation, antiinflammatory, regulation of vasodilation, reduction of platelet adhesion, influence of calcium ion channels, improvement of lipid distribution, involving in glucose metabolism and controlling blood sugar. This review reviewed the protective effects of G-Rb1 on CCVDs and its potential mechanisms, such as atherosclerosis (AS), hypertension, coronary heart disease (CHD), ischemic stroke (IS) and periocular microvascular retinopathy. Finally, we reviewed and reported the results of in vivo and in vitro experiments using G-Rb1 to improve CCVDs, highlighted its efficacy, safety, and limitations.
关键词:
人参皂苷Rb1;动脉粥样硬化;心脑血管疾病;冠心病;高血压;缺血性脑卒中;眼周微血管视网膜病变
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This work was supported by the grants of National Natural Science Foundation of China (No. 82104465).
Yueqin Song a, Chen Chen b, Wei Li a, c,d,*. Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms[J]. Chinese Herbal Medicines (CHM),2024,16(4):489-504
