Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. G. lucidum spores (GLS) are tiny germ cells released from the mushroom cap during the mature stage of growth. They contain all the genetic active substances of G. lucidum. G. lucidum spore oil (GLSO) is a lipid component extracted from broken-walled Ganoderma spores using supercritical CO2 extraction technology. GLSO contains fatty acids, Ganoderma triterpenes, sterols and other bioactive compounds. Previous studies have demonstrated that GLSO has a wide range of pharmacological properties, including anti-tumor, anti-aging, neuroprotection, immunomodulation, hepatoprotection and modulation of metabolic diseases. This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components, extraction and processing techniques, pharmacological effects and safety evaluation. This provides a solid foundation for further research and application of GLSO.
关键词:
抗衰老;抗肿瘤;生物活性成分;灵芝孢子油;护肝;免疫调节;药理作用
Keywords:
Project Supported:
The work was supported by Pearl River S&T Nova Program of Guangzhou (No. 201610010113), the Open Research Fund of NMPA Key Laboratory for Rapid Testing Technology of Drugs, Guangdong Institute for Drug Control (No. KF2022002, KF2022006) and Research Project of Chinese Medicine in TCM Bureau of Guangdong Province (No. 20231202). We thank Jinfang Ma and Fengjuan Jiang from Shenzhen JustHerb Biopharmaceutical Co., Ltd. for the help in supplying the GLSO.
Jianying Liu a, Binzhi Zhang a, Leqi Wang a, b, Shasha Li b, c, Qinqiang Long a,*, Xue Xiao a, c,*. Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review[J]. Chinese Herbal Medicines (CHM),2024,16(3):375-391
