Constipation is common in the diseases of the digestive system in clinics. With the change in diet structure and the increase in life pressure, the prevalence rate increases year by year. In traditional Chinese medicine (TCM), the location of the disease of constipation is in the large intestine, which is related to the dysfunction of lung, spleen, liver, kidney and other viscera. Its pathogenesis is conductive dysfunction of large intestine. Based on the theory, Shouhui Tongbian Capsule (SHTB) is composed of eight traditional Chinese medicines, including Polygoni multiflori Radix (Heshouwu in Chinese), Aloe (Luhui in Chinese), Cassiae Semen (Juemingzi in Chinese), Ginseng Radix et Rhizoma (Renshen in Chinese), Lycii Fructus (Gouqizi in Chinese), Asini Corii Colla (Ejiao in Chinese), Aurantii Fructus Immaturus (Zhishi in Chinese), and Atractylodis Macrocephalae Rhizoma (Baizhu in Chinese), which could help to release excessive turbid, and nourishing yin and supplementing qi in the treatment. This study has been carried out to review the latest advances of SHTB in the treatment of constipation. The results showed that significant effect of SHTB was found in the treatment of constipation, such as functional constipation, and constipation associated with tumor chemotherapy, colitis, type 2 diabetes and chronic cardiac failure. Besides, obvious adverse reactions were not observed. SHTB could effectively treat five types of constipation, provide direction for the future exploration of SHTB in the treatment of other types of constipation.
关键词:
便秘;胃肠激素;cajal间质细胞;肠液分泌;肠道蠕动;首荟通便胶囊
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Project Supported:
The work was supported by National Key R & D Program of China (No. 2022YFC3502100), Cutting Edge Development Fund of Advanced Medical Research Institute, Lunan Hope Pharmaceutical Co., Ltd. (No. 1520019013), the Scientific and Technological Innovation Program for Clinical Medicine of Jinan (No. 202019132) and Cultivation Fund Program of the Second Hospital of Shandong University (No. 2022YP14).
Liping Gong a, b, Hang Du a, Xin Guo c, Jianchao Li d, Xiaomin Zhu a, Xianhui Shen a, Zhiyan Huang b, Kaiyi Wu c, Guimin Zhang b,*, Rong Sun a, e,*. Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development[J]. Chinese Herbal Medicines (CHM),2024,16(2):239-247
