As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients’ physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine (TCM). In the early stage of fracture healing, the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor-1α (HIF-1α), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1α and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms, in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism.
关键词:
骨折愈合;缺氧;缺氧诱导因子-1α;中医药;分子机制
Keywords:
Project Supported:
This work is financially supported by National Natural Science Foundation of China (No. 82060877, 82104527), the Science and Technology Planning Project of Tibet Autonomous Region (No. XZ202101ZD 0022G), the Fundamental Research Funds for the Central Universities (No. lzujbky-2022-ct03).
Wenxian Zhang a,,*, Fusen Yang b,, Qikai Yan a, c,, Jiahui Li b, Xiaogang Zhang a, Yiwei Jiang a, Jianye Dai b,*. Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing[J]. Chinese Herbal Medicines (CHM),2024,16(1):56-69
