Medicinal plants are a valuable source of essential medicines and herbal products for healthcare and disease therapy. Compared with chemical synthesis and extraction, the biosynthesis of natural products is a very promising alternative for the successful conservation of medicinal plants, and its rapid development will greatly facilitate the conservation and sustainable utilization of medicinal plants. Here, we summarize the advances in strategies and methods concerning the biosynthesis and production of natural products of medicinal plants. The strategies and methods mainly include genetic engineering, plant cell culture engineering, metabolic engineering, and synthetic biology based on multiple ‘‘OMICS” technologies, with paradigms for the biosynthesis of terpenoids and alkaloids. We also highlight the biosynthetic approaches and discuss progress in the production of some valuable natural products, exemplifying compounds such as vindoline (alkaloid), artemisinin and paclitaxel (terpenoids), to illustrate the power of biotechnology in medicinal plants.
关键词:
：生物合成策略;生物技术;天然产物;药用植物;合成生物学
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This work was supported by National Natural Science Foundation of China (No. 81973422) and Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CIFMS, 2021-I2M-1-071).
Miaoxian Guo a, Haizhou Lv a, Hongyu Chen a, Shuting Dong a, Jianhong Zhang a, Wanjing Liu a, Liu He a, b, Yimian Ma a, b, Hua Yu c, Shilin Chen d, Hongmei Luo a, b,*. Strategies on biosynthesis and production of bioactive compounds in medicinal plants[J]. Chinese Herbal Medicines (CHM),2024,16(1):13-26
