Molecular mechanisms of isoflavone puerarin against cardiovascular diseases: What we know and where we go
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摘要:
Abstract:
Puerarin (Pue), known as a phytoestrogen, has salient bioactivities and is promising against cardiovascular diseases. This article summarizes the underlying molecular mechanisms of Pue in treating cardiovascular diseases, especially regulating the intracellular signal transduction, influencing ion channels, modulating the expression of microRNA, and impacting on the autophagy, which are mainly involved in the inflammatory signaling pathways, fatty acid/lipid metabolism, oxidative stress, apoptosis, and the like. The protective effect of Pue against cardiovascular diseases mainly involves attenuating the myocardial injury and decreasing the myocardial fibrosis, improving the myocardial ischemia/reperfusion injury, as well as inhibiting the myocardial hypertrophy and atherosclerosis. The molecular mechanisms of Pue’s cardiovascular protective effects for the first time and comment on the state-of-the-art research methods and principles of Pue’s regulation of small molecules were reviewed, so as to provide the rationale for its basic research and clinical applications.
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This work was supported by the National Key Research and Development Program of China [Grant No. 2017YFC1702901]; Fundamental Research Funds for the central public welfare research institutes [Project No. JBGS2021002]; China Academy of Chinese Medical Sciences (CACMS) innovation fund [Grant No. CI2021A05031].
Weida Qina, b, Jianghong Guoa, Wenfeng Goua, Shaohua Wua, b. Molecular mechanisms of isoflavone puerarin against cardiovascular diseases: What we know and where we go[J]. Chinese Herbal Medicines (CHM),2022,14(2):
