Investigating pharmacological mechanisms of andrographolide on non-alcoholic steatohepatitis (NASH): A bioinformatics approach of network pharmacology
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摘要:
Abstract:
Objective: To investigate the mechanisms of andrographolide against non-alcoholic steatohepatitis (NASH) based on network pharmacology, so as to provide a reference for further study of andrographolide in the treatment of NASH and other metabolic diseases. Methods: The methionine- and choline-deficient (MCD) diet-induced NASH mice were treated by administration of andrographolide, and serum transaminase and pathological changes were analyzed. The network pharmacology-based bioinformatic strategy was then used to search the potential targets, construct protein-protein interaction (PPI) network, analyze gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment, and conduct molecular docking to explore the molecular mechanisms. Results: The predicted core targets TNF, MAPK8, IL6, IL1B and AKT1 were enriched in non-alcoholic fatty liver disease (NAFLD) signaling pathway and against NASH by regulation of de novo fatty acids synthesis, anti-inflammation and anti-oxidation. Conclusion: This work provides a scientific basis for further demonstration of the anti-NASH mechanisms of andrographolide.
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This research was funded by the National Natural Science Foundation of China (31802242), Young Talents Visiting and Training Program for Foreign Country of Anhui Education Department (gxgwfx2019047), the National Natural Science Foundation of Anhui (2008085QC146), Natural Science Key Foundation of Anhui Education Department (KJ2017A503, KJ2017A504), Talent Project of Anhui Science and Technology University (ZRC2014447), and Key Research and Development Plan of Anhui Province (202004a06020050). Also, the authors would like to thank Dr. Ruth Wonfor, the Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, UK, for her good suggestion and language edit.
Lei Li a, b, Sheng-he Li a, Jin-peng Jiang a, Chang Liu a, *, Li-li Ji b,*. Investigating pharmacological mechanisms of andrographolide on non-alcoholic steatohepatitis (NASH): A bioinformatics approach of network pharmacology[J]. Chinese Herbal Medicines (CHM),2021,13(3):
