Objective To observe the lipid-lowering effect of Typha angustifolia extract (TAE) in Sprague Dawley rats. Methods The rats were randomly divided into six groups, including the hypercholesterolemic diet (HYD) group. Ad libitum food was given to the animals for 60 d to establish dyslipidemia models. The rats were received an ig administration of 1 mL medicine daily. After 120 d the animals were sacrificed by cervical dislocation; Blood was collected to measure total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), nitric oxide (NO), and endothelin (ET) plasma concentration; Livers were collected to measure ApoE mRNA and protein expression; And morphologic changes of aorta ventralis tissue were observed. Results Compared with HYD group, TAE had the ability of reducing TC, TG, LDL-C, NO, and ET (P < 0.01), thereby increasing ApoE mRNA and protein expression of the liver (P < 0.01). Conclusion These results suggest that TAE is capable of effectively decreasing the circulating lipids levels and enhancing the protective effects of artery.
关键词:
载脂蛋白E;高脂血症;蒲黄总黄酮
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This work was supported by Research Fund and Natural Science Foundation of Yichang City in Hubei Province, China (No. KFJ2013009; A14301-06).
