The drug metabolism in gut microbiota draws increasing attentions. After interacting with the gut bacteria, the biological effects of drugs might be altered, leading to toxicity or detoxification, production of potential bioactivities, regulating intestinal absorption, etc. In this review, we will focus on the metabolism of Chinese materia medica (CMM) in mammal gut microbiota and its biological effects to learn the interaction between gut bacteria and drugs through oral route in CMM.
National Mega-project for Innovative Drugs (2012ZX09301002), Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study (Z141102004414062), and National 863 Program of China (no. 2014AA020803)
Yan Wang, Jia-wen Shou, Jian-dong Jiang. Metabolism of Chinese Materia Medica in Gut Microbiota and Its Biological Effects[J]. Chinese Herbal Medicines (CHM),2015,7(2):109-115
