Objective To study the chemical constituents from the aerial parts of Hypericum beanii. Methods Various chromatographic techniques were used to separate the constituents and their structures were elucidated on the basis of extensive spectroscopic interpretation. Results Fifteen compounds were isolated from the aerial parts of H. beanii. Their structures were identified as hyperbeanol E (1), (E )-linalool-1-oic acid (2), (4S,5R )-5-(4′-methyl-3′-pentenyl)-4-hydroxy-5-methyl- dihydrofuran-2-one (3), benzoic acid (4), 4-(3-O-3″)-3″-methylbutenyl-6-phenyl- pyran-2-one (5), 4-hydroxy-4a,7-dimethoxy-4,4a-dihydrodibenzo-p-dioxin-2(3H )- one (6), isoimperatorin (7), 2,3-dimethoxyxanthone (8), 3,4-dihydroxy-2- methoxyxanthone (9), osajaxanthone (10), nigrolineaxanthone F (11), hypercohone G (12), betulinic acid (13), oleanolic acid 3β-caffeate (14), and isoastilbin (15). Conclusion Compound 1 is a new menthane monoterpene derivative which owns an extra lactone ring. Compounds 2–7 and 10–15 are isolated from genus Hypericum Linn. for the first time and the other compounds are first obtained from the plants in H. beanii.
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Project Supported:
National Natural Science Foundation of China (31300293, 81422046); General Project of Applied Foundation Research, Yunnan Province (2013FB067); Basic Research Project of Ministry of Science and Technology of China (2012FY110300); Major State Basic Research Development Program (2010CB951704; Youth Innovation Promotion Association CAS and SRF for ROCS, SEM to W.-L. Xiao.
