Objective To study the water-soluble chemical constituents rhizomes of from Atratylodes lancea. Methods Two sesquiterpenoid glycosides were purified by column chromatography and their structures were determined by spectroscopic analysis. They were also evaluated for anti-inflammatory activity by determining the inhibitory activity on LPS-induced NO and PGE2 generation in RAW 264.7 cell lines. Results Compound 1 was a new sesquiterpenoid glycoside, named as (1S,4S,5R,7R,10S)-4,11,14-trihydroxy- guai-3-one-11-O-β-D-glucopyranoside, but exhibited no appreciable activity. Compound 2 was atractyloside A and showed weak activity. Conclusion The hydroxy methyl group at C-10 of guaiol-type glycoside could be important for anti- inflammatory activity.

Project Supported:

Open Fund of Jiangsu Key Laboratory for Bioresources of Saline Solis (JKLB2013005)

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