Gastroprotective Effects of Ascaridole on Gastric Ulcer in Rats
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Abstract:
Objective To evaluate the gastroprotective activity of ascaridole. Methods The gastroprotective effect of ascaridole was evaluated on ulcer healing in rats with acetic acid-induced chronic gastric ulcer, pylorus ligation- and Aspirin- induced gastric ulcer. Ascaridole was ig administered with the dosages of 10 and 20 mg/kg once daily for 7 d. Results Ascaridole showed the significant anti-ulcer effects. In acetic acid-induced gastric ulcer rats, the ulcer areas after 10 and 20 mg/kg of ascaridole treatment were (65.1 ± 20.0) and (50.6 ± 11.0) mm2, respectively, which were significant lower (P < 0.01) than that of the control group [(116.7 ± 35.8) mm2]. For pylorus ligation model, ascaridole showed a gastric ulcer healing effect in a dose-dependent manner. Ascaridole at the dose of 20 mg/kg showed 50% ulcer protection and had a significant (P < 0.05) gastroprotective activity since it decreased the total acidity and pepsin activity. Compared to the control group, the two dosages of ascaridole showed the significant reduction (P < 0.05) in the ulcer index on Aspirin-induced ulcer. Conclusion This study provides evidence that ascaridole shows potential efficacy on the healing of gastric ulcers induced by acetic acid, Aspirin, and pylorus ligation.
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National Key Special Project of Science and Technology for Innovation Drugs of China (2008ZX09401-006)
ZHU Yong-hong, LI Xin-xin, MO Hong-mei, ZHANG Li-hua, ZHANG Lan-lan, ZHOU Shui-ping, MA Xiao-hui, ZHANG Bo-li. Gastroprotective Effects of Ascaridole on Gastric Ulcer in Rats[J]. Chinese Herbal Medicines (CHM),2012,4(1):58-62
