Objective To identify the active compounds for protein tyrosine phosphatase 1B (PTP1B) from the seeds of Plantago asiatica. Methods Bioassay-guided fractionation resulted in the isolation of iridoid glucosides (1－5) with PTP1B inhibitory activity. Results Five compounds were identified as desacetylhookerioside (1), melittoside (2), geniposidic acid (3), 10-O-acetyl-geniposidic acid (4), and alpinoside (5). Conclusion Isolated compounds 3－5 inhibit PTP1B with IC50 values ranged from (16.3 ? 1.1) to (19.8 ? 1.2) μmol/L.
Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (JWSL-2009-1590); Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules (Yanbian University), Ministry of Education, China (CSSHZ-2009-05)
[8]Schripsema Jan,Caprini Geisa Paulino,van der Heijden Rob,Bino Raoul,de Vos Ric,Dagnino Denise.Iridoids from Pentas lanceolata[J].Journal of natural products,2007,70(9):1495-1498.
CUI Long, LEE Hyun-sun, AHN Jong-seog, YUAN Guang-xin, SUN Ya-nan. Protein Tyrosine Phosphatase 1B Inhibitors from Plantago asiatica[J]. Chinese Herbal Medicines (CHM),2011,3(2):136-139
