Objective To study the triterpene saponins from Gynostemma pentaphyllum with antitumor activities. Methods The 75% EtOH extract of G. pentaphyllum was used for isolation by silica gel column chromatography and preparative HPLC. The structures of pure compounds isolated were identified by the spectral analysis and chemical evidence. Results Two compounds were isolated and identified as 23(S)-3β,20ξ,21ξ-trihydroxy-19-oxo-21,23- epoxydammar-24-ene 3-O-α-L-rhamnopyranosyl (1→2)-[β-D-xylopyranosyl (1→3)]-β-D-arabinopyranoside (1) and 23(S)-21(R)-O-n-butyl-3β,20ξ-dihydroxy-21,23-epoxydammar-24-ene 3-O-α-L-rhamnopyranosyl (1→2)-[β-D- xylopyranosyl(1→3)]-β-D-arabinopyranoside (2). Conclusion Compound 2 is a new triterpene saponin with moderate antitumor activities against the HL-60, Colon205, and Du145 cell lines.
[8]CHE Yan-Yun ,LI Ning ,ZHANG Liang ,TU Peng-Fei ,Key Laboratory of Modern Chinese Medicines,Ministry of Education.Triterpenoid Saponins from the Leaves of Ilex kudingcha[J].Chinese JOurnal of Natural Medicines,2011(1):22-25.
SHI Lin, CAO Jia-qing, ZHAO Hong, ZHAO Yu-qing. A New Triterpene Saponin from Gynostemma pentaphyllum[J]. Chinese Herbal Medicines (CHM),2010,2(4):317-320
