Regulation of Fengxiaofang on Expression of Gene Gob-5 in Asthmatic Mice
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Abstract: Objective To observe the regulation of Fengxiaofang on the expression of gene Gob-5 in ovalbumin-challenged asthmatic mice. Methods The murine model of allergic asthma established by ovalbumin was used. The model mice were treated experimentally with Fengxiaofang and Dexamethasone as a positive control. The quantitive expression of gene Gob-5 in lung of mice was detected by real-time quantitative PCR. Results The expression of gene Gob-5 in lung of mice was down-regulated by Fengxiaofang. In the experiment, there were no significant differences between the one-fold or ten-fold dosage groups and the normal control group. Gene Gob-5 expression in five-fold dosage was significantly lower than that in the normal control group. Conclusion Fengxiaofang has the effect of lowering the expression of gene Gob-5 which maybe related to the potency on asthmatic disease.
BAI Gen-ben, LIU Yang, LI You-lin, MA Xiao-xin, YAN Shi, FAN Chang-zheng, GUO Ya-hong. Regulation of Fengxiaofang on Expression of Gene Gob-5 in Asthmatic Mice[J]. Chinese Herbal Medicines (CHM),2010,2(1):68-71
