A New Sesquiterpenoid Glycoside from Rhizomes of Atractylodes lancea
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Abstract:
Objective To study the water-soluble chemical constituents from the rhizomes of Atractylodes lancea. Methods Two sesquiterpenoid glycosides were purified by column chromatography and their structures were determined by spectroscopic analysis. They were also evaluated for anti-inflammatory activity by determining the inhibitory activity on LPS-induced NO and PGE2 generation in RAW 264.7 cell lines. Results Compound 1 was a new sesquiterpenoid glycoside, named as(1S,4S,5R,7R,10S)-4,11,14-trihydroxy-guai-3-one-11-O-β-D-glucopyranoside, but exhibited no appreciable activity. Compound 2 was atractyloside A and showed weak activity. Conclusion The hydroxyl group at C-10 of guaiol-type glycoside could be important for anti-inflammatory activity.
Min Yin, Chao-cheng Xiao, Yu Chen, Ming Wang, Fu-qin Guan, Qi-zhi Wang, Yu Shan, Xu Feng. A New Sesquiterpenoid Glycoside from Rhizomes of Atractylodes lancea[J]. Chinese Herbal Medicines (CHM),2015,7(4):371-374
