[关键词]
[摘要]
中药防治阿尔茨海默病(Alzheimer's disease,AD)是当前人们关注的研究热点。石菖蒲Acorus tatarinowii提取物及其所含化学成分在中枢神经系统可发挥多种药理作用,其中以主要活性部位和化学成分(如挥发油和β-细辛醚等)近年来在改善学习记忆和防治AD方面的报道最多。在查阅相关国内外文献基础之上,概述了石菖蒲提取物及其主要化学成分对AD不同药效作用及其作用机制的研究进展。
[Key word]
[Abstract]
Currently, Chinese materia medica is a research hotspot on the treatment of Alzheimer's disease(AD). The extracts from Acorus tatarinowii have a variety of pharmacological effects on the central nervous system, among which the volatile oil and β-asarone are the main active ingredients in A. tatarinowii reported on the effect on improving the learning and memory and prevention of AD. This review focuses on the main active ingredients in A. tatarinowii and progresses in their different therapeutic effects and proposed pharmacological mechanisms for AD on the basis of referring to the relevant literatures at home and abroad.
[中图分类号]
[基金项目]
天津市应用基础及前沿技术研究计划一般项目"中药抗抑郁作用及其NMDA受体机制研究"(12JCYBJC32400)