蔓荆子是发散风热的传统中药材,《中国药典》2015年版规定其基原植物为单叶蔓荆Vitex trifolia var. simplicifolia 或蔓荆Vitex trifolia。化学成分研究表明上述2种基原植物含有萜类、黄酮类、蒽醌类、木脂素类、酚酸类等化学成分。药理学研究表明其具有抗炎、抗氧化、解热镇痛、抑制组胺释放、抗肿瘤等多种生物活性。对蔓荆的化学成分和药理作用研究进展进行综述,以期对蔓荆的深入研究提供参考。

Viticis Fructus is a traditional Chinese materia medica with wind-heat-dispersing action and its original plant recorded in Chinese Pharmacopoeia is Vitex trifolia var. simplicifolia or V. trifolia. Chemical investigation indicated that the two plants contained terpenes, flavonoids, anthraquinones, lignanoids, phenolic acids, and other ingredients. Modern pharmacological studies had shown the anti-inflammatory, anti-oxidative, antipyretic-analgesic, histamine release inhibiting, antitumor activities, and so on. In this paper, the chemical constituents and pharmacological effects are reviewed, which can provide the references for further study on V. trifolia.

国家高技术研究发展计划(“863”计划)资助项目(2013AA093001);科技部重大新药创制项目(2012ZX09103-201-046);天津市高等学校科技发展基金计划项目(20140147);天津市高等学校创新团队培养计划(TD12-5033)