天然黄酮类化合物是以C₆-C₃-C₆为基本结构骨架,结构亚型多种多样;其在自然界中的分布极为广泛,从水果、蔬菜到中药中都有发现,生物活性具有多样性,一直是药物研发的热点领域.以天然黄酮类化合物为先导化合物或直接开发成的药物已经得到广泛应用.由于黄酮类化合物的结构具有极强的规律性,对于该类化合物的构效关系研究也很活跃,也为药物研发提供了丰富的理论依据.总结了近年来黄酮类化合物构效关系的研究进展,为分离或合成具有更强药理活性的黄酮类先导化合物提供理论参考.

Flavonoids are a large type of compounds in natural products, and they have varied structure subtypes, with the basic structural framework of C₆-C₃-C₆. Flavonoids are widely distributed in nature, from fruits and vegetables to Chinese materia medica, and they have also been found to have a wide variety of biological activities, so they have always been the hot spot of the drug development. Flavonoids as lead compounds or directly developed drugs have already been widely used. Lots of studies have been reported about structure-activity relationship of flavonoids. This review summarized research progress of structure-activity relationship of flavonoids in recent years.

国家自然科学基金资助项目(81302664);河北省自然科学基金资助项目(H2013206103);河北医科大学国家级大学生创新性实验计划项目(USIP201422A)