目的制备β-榄香烯固体脂质纳米粒,并对其粒径和包封率进行考察。方法采用薄膜-超声分散法制备,并以包封率为指标采用正交设计法优化β-榄香烯固体脂质纳米粒的制备工艺。结果所得β-榄香烯固体脂质纳米粒的最佳制备条件是β-榄香烯20μL,卵磷脂90mg,硬脂酸90mg,2.5%聚山梨酯805mL,2.5%泊洛沙姆1885mL。结论该处方可用于β-榄香烯固体脂质纳米粒的制备,工艺可行。

Objective To prepare β-elemene solid lipid nanoparticles and investigate their particle size diameter and entrapment efficiency.Methods The β-elemene solid lipid nanoparticles were prepared by film ultrasonic wave dissolving techniques.And the optimum formula was selected through orthogonal design test according to the entrapment efficiency.Results The optimizing technique was β-elemene(20 μL),stearic acid(90 mg),lecithin(90 mg),Tween80(2.5 %,5 mL) and Poloxamer 188(2.5 %,5 mL).Conclusion The technique of preparing β-elemene by film-ultrasonic wave dissolving technique is feasible.