[关键词]
[摘要]
目的研究血脂康胶囊中的化学成分。方法通过硅胶、Sephadex LH-20柱色谱,结合重结晶技术,从血脂康胶囊中分离得到9个化合物,经理化性质鉴定、波谱解析以及与已知化合物对照,鉴定其结构。结果分别鉴定为脱水莫纳可林K(Ⅰ)、豆甾-5,22-二烯-3β-醇(Ⅱ)、莫纳可林K(Ⅲ)、3β-羟基-5α,8β-环二氧麦角甾-6,22-二烯(Ⅴ)、N-[1-(四氢-5-氧代呋喃-2)-乙基]乙酰唑胺(Ⅵ)、大豆苷元(Ⅶ)、黄豆黄素(Ⅷ)、染料木素(Ⅸ)、赤藓醇(Ⅹ)。结论以上化合物除Ⅰ、Ⅲ外,均首次从血脂康胶囊中分离得到。化合物Ⅵ为新的天然产物。
[Key word]
[Abstract]
Objective To study the chemical constituents of Xuezhikang Capsula.Methods Silica gel and Sephadex LH-20 were used to isolate the compounds,EI,FAB-MS,and 1D and 2D-NMR were used to identify the obtained compounds.Results Nine compounds were obtained from the capsula,they were charactered as dehydromonacolin K (Ⅰ),stigmasta-5,22-dien-3β-ol (Ⅱ),monacolin K (Ⅲ)3β-hydroxy-5α,8β epidioxyergostera-6,22-diene (Ⅴ),N-[1-(tetrahydro-5-oxofuran-2-yl)-ethyl] acetamide (Ⅵ),7,4'-dihydroxy-isoflavone (Ⅶ),7,4'-dihydroxyisoflavone-6-methoxyisoflavone (Ⅷ),5,7,4-trihydroxyiso-flavone (Ⅸ),erythritol (Ⅹ).Conclusion They are all obtained from the capsula exceptⅠand Ⅲ for the first time,among them Ⅵ is a new natural compound.
[中图分类号]
[基金项目]