目的 通过广枣总黄酮 (TFCA)对阿霉素 (ADR)引起大鼠心肌过氧化损伤保护作用的研究,进一步证实广枣疗效可能与 TFCA抗氧化作用有关。方法 动物分为空白组、ADR组和实验组 (ADR+TFCA10 0,15 0,2 0 0mg/ kg组)。以“心酶谱”、抗氧化酶做为检测指标。结果 ADR组心酶谱、MDA均比空白组高,而抗氧化酶活性均比空白组低。TFCA干预后“心酶谱”、MDA下降,抗氧化酶活性上升。结论 TFCA能抑制 ADR所引起大鼠心肌过氧化损伤。

Object By studying the protective effect of total flavonoids of Choerospondias axillaris (Roxb) Burtt et Hill (TFCA) on rat myocardiac injury caused by adriamycin (ADR) to provide further evidence showing the action of this medicinal herb is related to its antioxidation activities.Methods Test animals were randomized into four groups: blank control, ADR control, and three experimental groups (ADR+TFCA 100, 150 and 200 mg/kg) The antioxidation enzyme activities were assessed by cardiac zymogram.Results Cardiac zymogram showed that malondialdehyde (MAD) of the ADR control was higher while the antioxidation enzyme activities were lower than the blank control With the intervention of TFCA, cardiac zymogram showed lowering of MDA and elevation of antioxidation enzyme activities.Conclusion TFCA can inhibit rat myocardiac peroxidation injury caused by ADR

内蒙古自然科学基金资助(NO.9713031)