[关键词]
[摘要]
对葫芦科植物山苦瓜 Momoridica dioica干燥块根的浸膏进行了分离、提纯,用L1210、CCER-CEM、LS174T癌细胞对其成分进行了体外筛选,5个化合物具有抗癌活性,经光谱鉴定,它们是拜俄尼酸(Ⅷ)、雪胆甲素(ⅩⅠ)、α-菠甾醇-3-O-β-D-吡喃葡萄糖苷、丝石竹皂苷元(Ⅴ)及常春藤皂苷元(Ⅶ).
[Key word]
[Abstract]
Five anti-cancer compounds were isolated from the dried root of Momordica dioica Koxb. ex Willd. They were identified as bryonolic acid, 23, 24-dihydrocucurbitacin-F-25-acetate, α-spinasterol-3-O-β-D-glucopyranoside; gypsogenin and hederagenin by spectroscopic (MS, IR, 1HNMR, 13CNMR and DEPT) data. All of them were found to possess anti-cancer activities against L1210, CCER-CEM, Ls174T cell lines by pharmacological screenings.
[中图分类号]
[基金项目]
国家自然科学基金