白术-白芍药对的物质基础及作用机制研究进展

doi:10.7501/j.issn.0253-2670.2025.07.031

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2025年6月25日 20:52 星期三

首页 > 过刊浏览>2025年第56卷第7期 >2025,56(7):2582-2592. DOI:10.7501/j.issn.0253-2670.2025.07.031

白术-白芍药对的物质基础及作用机制研究进展

王世新
王世新
黑龙江中医药大学, 黑龙江哈尔滨 150040
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王秋艳
王秋艳
黑龙江中医药大学, 黑龙江哈尔滨 150040
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李爽
李爽
黑龙江中医药大学, 黑龙江哈尔滨 150040
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隋方宇
隋方宇
黑龙江中医药大学, 黑龙江哈尔滨 150040
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张淼
张淼
黑龙江中医药大学, 黑龙江哈尔滨 150040
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胥风华
胥风华
黑龙江中医药大学附属第一医院, 黑龙江哈尔滨 150040
通讯作者.
Email: fenghua23456@sina.com
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旺建伟
旺建伟
黑龙江中医药大学, 黑龙江哈尔滨 150040
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Email: wangjianweilikai@163.com
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Research progress on material basis and mechanism of action of Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba herb pair

WANG Shixin
WANG Shixin
Heilongjiang University of Chinese Medicine, Harbin 150040, China
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WANG Qiuyan
WANG Qiuyan
Heilongjiang University of Chinese Medicine, Harbin 150040, China
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LI Shuang
LI Shuang
Heilongjiang University of Chinese Medicine, Harbin 150040, China
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SUI Fangyu
SUI Fangyu
Heilongjiang University of Chinese Medicine, Harbin 150040, China
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ZHANG Miao
ZHANG Miao
Heilongjiang University of Chinese Medicine, Harbin 150040, China
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XU Fenghua
XU Fenghua
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China
Contact Author.
Email: fenghua23456@sina.com
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WANG Jianwei
WANG Jianwei
Heilongjiang University of Chinese Medicine, Harbin 150040, China
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Email: wangjianweilikai@163.com
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发布日期：2025-04-03

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[关键词]

白术-白芍 ; 药对 ; 配伍 ; 物质基础 ; 白术内酯 ; 芍药苷 ; 芍药内酯苷

[摘要]

白术Atractylodis Macrocephalae Rhizoma-白芍Paeoniae Radix Alba为临床常用药对，二药配伍后相使而行，善于调和肝脾。以白术-白芍为核心或组成部分的方剂，其功效在不同的方剂配伍情境下存在差异。白术-白芍富含多种化学成分，因炮制方法、药物配比、检测条件等因素不同，其主要成分白术内酯、芍药苷、芍药内酯苷等经配伍、炮制后含量也有所变化。白术-白芍治疗疾病机制聚焦于胃肠功能调节、抗炎、调节免疫及神经保护方面。通过对相关文献的检索与整理，主要从复方配伍、物质基础及作用机制方面对白术-白芍药对进行系统论述，为该药对的深入研究及开发应用提供思路和科学依据。

[Key word]

Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba ; herb pair ; compatibility ; material basis ; atractylenolide ; paeoniflorin ; paeonilactone glycoside

[Abstract]

Baizhu (Atractylodis Macrocephalae Rhizoma)-Baishao (Paeoniae Radix Alba) is commonly used clinical drug pairs. After the two drugs are combined, they work together and are good at harmonizing the liver and spleen. The efficacy of prescriptions with Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba as the core or component varies in different prescription compatibility situations. Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba are rich in a variety of chemical components. Due to different processing methods, drug ratios, detection conditions and other factors, the content of its main components, such as atractylenolide, paeoniflorin, and paeoniflorin, also changes after compatibility and processing. The mechanism of Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba in treating diseases focuses on gastrointestinal function regulation, anti-inflammation, immune regulation and neuroprotection. This study systematically discusses Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba pair from the aspects of compound compatibility, material basis and mechanism of action through the retrieval and collation of relevant literature, in order to provide ideas and scientific basis for the in-depth research and development and application of this drug pair.

[中图分类号]

R285

[基金项目]

国家自然科学基金面上项目（81573870）；国家中医药管理局第五批全国中医临床优秀人才研修项目（国中医药人教函 [2022] 239号）；第五批全国中医临床优秀人才研修项目（国中医药人教函[2022] 1号）；全国中医药创新骨干人才培养项目（国中医药人教函[2019] 128号）

引用本文 / Get Citation

王世新,王秋艳,李爽,隋方宇,张淼,胥风华,旺建伟.白术-白芍药对的物质基础及作用机制研究进展[J].中草药,2025,56(7):2582-2592

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收稿日期: 2024-12-10

在线发布日期: 2025-04-03

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