摘要： 目的 探讨保胎无忧片联合盐酸利托君治疗晚期先兆流产的临床疗效。 方法 选取2013年7月-2015年3月泸州医学院附属医院妇产科收治的晚期先兆流产患者100例，随机分为对照组和治疗组，每组各50例。对照组患者静脉滴注注射用盐酸利托君，100 mg加入5%葡萄糖溶液500 mL，起始速度5滴/min，根据患者宫缩情况每10分钟增加5滴，最大速度35滴/min，宫缩抑制后继续滴注12 h，停药前30 min口服盐酸利托君片，第1天1片/2 h，第2天1片/4 h，第3～10天1片/6 h，每日总量不超过120 mg。治疗组在对照组治疗基础上口服保胎无忧片，4片/次，2次/d。两组患者均治疗14 d。观察两组的临床疗效，同时比较两组临床症状及宫缩消失时间及妊娠延长时间，孕酮及人绒毛膜促性腺激素（HCG）水平变化情况。 结果 治疗后，对照组和治疗组的总有效率分别为82.0%、90.0%，两组比较差异具有统计学意义（P<0.05）。治疗组患者临床症状及宫缩消失时间显著短于对照组，治疗组患者妊娠延长时间显著长于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者孕酮及HCG水平均显著升高，同组治疗前后差异有统计学意义（P<0.05）；治疗组这些指标的改善程度优于对照组，两组比较差异有统计学意义（P<0.05）。 结论 保胎无忧片联合盐酸利托君治疗晚期先兆流产临床疗效较好，能够显著升高孕妇孕酮及HCG水平，且不良反应发生率低，具有一定的临床推广应用价值。

Abstract: Objective To explore the clinical effects of Baotai Wuyou Tables combined with ritodrine hydrochloride in treatment of late threatened abortion. Methods Patients (100 cases) with late threatened abortion in Department of Obstetrics and Gynecology of Affiliated Hospital of Luzhou Medical College from July 2013 to March 2015 were randomly divided into control (50 cases) and treatment (50 cases) groups. The patients in the control group were iv administered with Ritodrine Hydrochloride for injection, 100 mg added into 5% Glucose Solution 500 mL, and the starting speed was 5 drops/min, the speed was increased five drops every 10 min according to the contractions situation, and the maximum speed was 35 drops/min. The patients were continued to drip for 12 h after contractions inhibition. The patients in the control group were po administered with Ritodrine Hydrochloride Tablets 30 min before discontinuation, 1 tablet/2 h on the first day, 1 tablet/4 h on the second day, 1 tablet/6 h from the third to the tenth day, and total amount was not more than 120 mg/d. The patients in the treatment group were po administered with Baotai Wuyou Tables on the basis of the control group, 4 tablets/time, twice daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, clinical symptoms disappeared time and pregnancy prolong time in two groups were compared. The changes of progesterone and HCG before and after treatment in two groups were compared. Results After treatment, the total efficacies in the control and treatment groups were 82.0% and 90.0%, respectively, and there were differences between two groups (P<0.05). After treatment, disappeared time of clinical symptoms and contractions in the treatment group were significantly shorter than those in the control group, and pregnancy prolong time in the treatment group was longer than that in the control group, and there were differences between two groups (P<0.05).The levels of progesterone and HCG in two groups were increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the improvement of these observations indicators in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusions Baotai Wuyou Tables combined with ritodrine hydrochloride has clinical curative effect in treatment of late threatened abortion, and can increase the levels of progesterone and HCG significantly with less adverse reactions, which has a certain clinical application value.