目的 探讨丹参注射液联合替格瑞洛片治疗急性心肌梗死的临床疗效。方法 选取宜兴市人民医院2020年2月—2023年8月收治的72例急性心肌梗死患者，按照随机数字表法将所有患者分为对照组（36例）和治疗组（36例）。对照组口服替格瑞洛片，1片/次，2次/d。治疗组在对照组基础上静脉滴注丹参注射液，10 mL加入300 mL葡萄糖注射液，1次/d。所有患者持续治疗2周。比较两组的临床疗效、胸痛程度、心功能指标和血清指标。结果 治疗组总有效率为94.44%，对照组总有效率为77.78%，组间差异显著（P＜0.05）。治疗后，两组的胸痛发作频率、发作持续时间均比治疗前小（P＜0.05），且治疗组胸痛发作频率、发作持续时间明显比对照组小（P＜0.05）。治疗后，两组的左室射血分数（LVEF）、每搏输出量（SV）、心脏排血指数（CI）均高于治疗前（P＜0.05），且治疗组LVEF、SV、CI比对照组高（P＜0.05）。治疗后，两组的载脂蛋白A（Apo-A）水平显著升高，超敏肌钙蛋白（hs-cTn）、脂蛋白相关磷脂酶A2（Lp-PLA2）水平显著降低（P＜0.05）；治疗组的Apo-A水平高于对照组，hs-cTn、Lp-PLA2水平低于对照组（P＜0.05）。结论 丹参注射液联合替格瑞洛片治疗急性心肌梗死的疗效确切，可减轻胸痛程度，提高心功能，减轻心肌损伤。

Objective To investigate the clinical effect of Danshen Injection combined with Ticagrelor Tablets in treatment of acute myocardial infarction. Methods Patients (72 cases) with acute myocardial infarction in Yixing People's Hospital from February 2020 to August 2023 were divided into control and treatment groups according to the random number table method, and each group had 36 cases. Patients in the control group were po administered with Ticagrelor Tablets, 1 tablet/time, twice daily. Patients in the treatment group were iv administered with Danshen Injection on the basis of the control group, 10 mL added into 300 mL glucose injection, once daily. Patients in two groups were treated for 2 weeks. The clinical efficacies, the degree of chest pain, the cardiac function indicators, and the serum indicators in two groups were compared. Results The total effective rate of the treatment group was 94.44%, while the total effective rate of the control group was 77.78%, with a significant difference between the groups (P < 0.05). After treatment, the frequency and duration of chest pain attacks in both groups were lower than those before treatment (P < 0.05), and the indexes in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, LVEF, SV, and CI of two groups were higher than before treatment (P < 0.05), and the cardiac function indicators of the treatment group were higher than those of the control group (P < 0.05). After treatment, the levels of Apo-A in two groups significantly increased, while the levels of hs-cTn and Lp-PLA2 in two groups significantly decreased (P < 0.05). The levels of Apo-A in the treatment group was higher than that in the control group, while the levels of hs-cTn and Lp-PLA2 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Danshen Injection combined with Ticagrelor Tablets can improve the efficacy of acute myocardial infarction, reduce the degree of chest pain, improve heart function, and alleviate myocardial damage.

R972

江苏大学教育教学改革与研究课题（临床医学专项）（JLY2021220）