目的 探讨益心康泰胶囊联合阿托伐他汀钙片治疗高脂血症的临床疗效。方法 选取2020年1月—2021年4月河南省胸科医院收治的82例高脂血症患者作为研究对象，按照随机数字表法将所有患者分为对照组和治疗组，每组41例。对照组口服阿托伐他汀钙片，20 mg/次，1次/d。治疗组患者在对照组基础上口服益心康泰胶囊，1.0 g/次，3次/d。两组患者连续治疗2个月。观察两组的临床疗效，比较两组生活质量、血脂和血清血管内皮功能指标水平。结果 治疗后，治疗组的总有效率为95.12%，对照组的总有效率为80.49%，两组间有明显差异（P<0.05）。治疗后，两组的生活质量综合评定问卷（GQOLI-74）评分显著升高，差异具有统计学意义（P<0.05），且治疗组GQOLI-74评分升高更明显，差异具有统计学意义（P<0.05）。治疗后，两组的三酰甘油（TG）、总胆固醇（TC）、TC-高密度脂蛋白胆固醇（HDL-C）/HDL-C显著降低，HDL-C明显升高（P<0.05）；且治疗组的TG、TC、TC-HDL-C/HDL-C低于对照组，HDL-C高于对照组，差异具有统计学意义（P<0.05）。治疗后，两组的内皮素-1（ET-1）、白细胞介素-6（IL-6）水平显著降低，一氧化氮（NO）水平显著升高（P<0.05）；治疗组的ET-1、IL-6水平低于对照组，NO水平高于对照组，差异有统计学意义（P<0.05）。结论 益心康泰胶囊联合阿托伐他汀钙片治疗高脂血症的疗效确切，能改善患者的生活质量，降低血脂，调节血管内皮功能，安全性良好。

Objective To investigate the clinical efficacy of Yixinkangtai Capsules combined with Atorvastatin Calcium Tablets in treatment of hyperlipidemia. Methods Patients (82 cases) with hyperlipidemia in Henan Provincial Chest Hospital from January 2020 to April 2021 were divided into control and treatment groups according to the random number table method, and each group had 41 cases. Patients in the control group were po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Yixinkangtai Capsules on the basis of the control group, 1.0 g/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and the quality of life, the blood lipids, and the serum levels of vascular endothelial function fators in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.12%, while that of the control group was 80.49%, and there was a significant difference between the two groups (P < 0.05). After treatment, the GQOLI-74 scores of two groups were significantly increased (P < 0.05), and the GQOLI-74 scores of the treatment group were significantly higher than those of the control group (P < 0.05). After treatment, the TG, TC, and TC-HDL-C/HDL-C in two groups were significantly decreased, but the HDL-C in two groups were significantly increased (P < 0.05). The levels of TG, TC, and TC-HDL-C/HDL-C in the treatment group were lower than those in the control group, but the HDL-C in the treatment group was higher than those in the control group (P < 0.05). After treatment, the levels of ET-1 and IL-6 in two groups were significantly decreased, but the level of NO in two groups were significantly increased (P < 0.05). And the levels of ET-1 and IL-6 in the treatment group were lower than those in the control group, but the level of NO in the treatment group was higher than that in the control group (P < 0.05). Conclusion Yixinkangtai Capsules combined with Atorvastatin Calcium Tablets has clinical effect in treatment of hyperlipidemia, can further improve the quality of life of patients, reduce blood lipid, regulate vascular endothelial function, with good safety.

R972

河南省医学科技攻关计划项目（2018020856）