[关键词]
[摘要]
目的 观察贞芪扶正胶囊联合异维A酸胶丸治疗扁平疣的临床疗效。方法 选取2015年7月—2016年6月上海市第八人民医院收治106例扁平疣患者,随机分为对照组和治疗组,每组各53例。对照组患者口服异维A酸胶丸,10 mg/次,2次/d;治疗组患者在对照组基础上口服贞芪扶正胶囊,4粒次,2次/d。两组患者均连续治疗4周。比较两组患者治疗前后临床疗效、血清免疫球蛋白IgG和外周血T淋巴细胞亚群水平,并观察患者不良反应情况。结果 治疗后,对照组和治疗组的总有效率分别为69.81%和88.68%,两组比较差异有统计学意义(P < 0.05)。治疗后,两组患者IgG、CD3+和CD4+水平均比治疗前显著升高,同组比较差异具有统计学意义(P < 0.05);且治疗组上述指标升高情况显著好于对照组,两组比较差异具有统计学意义(P < 0.05)。结论 贞芪扶正胶囊联合异维A酸胶丸治疗扁平疣,临床疗效确切,皮损改善明显,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To observe the clinical effect of Zhenqi Fuzheng Capsules combined with Isotretinoin Soft Capsules in treatment of flat wart.Methods Patients (106 cases) with flat wart in the Eighth People's Hospital of Shanghai from July 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 53 cases. Patients in the control group were po administered with Isotretinoin Soft Capsules, 10 mg/time, twice daily. Patients in the treatment group were po administered with Zhenqi Fuzheng Capsules on the basis of the control group, 4 granules/time, twice daily. Patients in two groups were treated for four weeks. After treatment, the clinical efficacy, serum immunoglobulin IgG and peripheral blood T lymphocyte subsets in two groups before and after treatment were compared, and the adverse reaction was observed. Results After treatment, the clinical efficacies in the control and treatment groups were 69.81% and 88.68% respectively, and there was difference between two groups (P < 0.05). After treatment, IgG, CD3+, and CD4+ level in two groups significantly increased, the difference was statistically significant in the same group (P < 0.05). And the increase of those indicators in the treatment group was significantly better than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Zhenqi Fuzheng Capsules combined with Isotretinoin Soft Capsules has an exact clinical curative effect in treatment of flat wart with significant skin lesions improvement, which has a certain clinical application value.
[中图分类号]
[基金项目]