Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke
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摘要:
缺血性脑卒中（Ischemic stroke, IS）是一种严重的脑血管疾病，发病率、致残率和死亡率都很高。重组组织纤溶酶原激活剂（Recombinant tissue plasminogen activator, r-tPA）是IS的一线治疗药物。然而，由于治疗窗口期较窄，且存在出血风险，致使许多患者难以获得有效治疗。中医药在预防和治疗 IS 方面具有明显优势。中医药能够增强脑微循环、缓解神经功能紊乱、调节能量代谢、减轻炎症反应、抑制氧化应激损伤和细胞凋亡，从而减轻脑损伤和预防IS复发。本文从中医角度总结了IS的病因、病机、治疗策略以及与现代生物学的关系，详细讨论了中医药防治IS的优势，并进一步综述了中医药在IS急性期、恢复期以及中风后并发症中的药效学特点和优势。这为中医药防治在 IS的临床应用以及新型药物的开发提供了宝贵的见解和参考。
Abstract:
Ischemic stroke (IS) is a severe cerebrovascular disease with a high incidence, mortality, and disability rate. The first-line treatment for IS is the use of recombinant tissue plasminogen activator (r-tPA). Regrettably, numerous patients encounter delays in treatment due to the narrow therapeutic window and the associated risk of hemorrhage. Traditional Chinese medicine (TCM) has exhibited distinct advantages in preventing and treating IS. TCM enhances cerebral microcirculation, alleviates neurological disorders, regulates energy metabolism, mitigates inflammation, reduces oxidative stress injuries, and inhibits apoptosis, thereby mitigating brain damage and preventing IS recurrence. This article summarizes the etiology, pathogenesis, therapeutic strategies, and relationship with modern biology of IS from the perspective of TCM, describes the advantages of TCM in the treatment of IS, and further reviews the pharmacodynamic characteristics and advantages of TCM in the acute and recovery phases of IS as well as in post-stroke complications. Additionally, it offers valuable insights and references for the clinical application of TCM in IS prevention and treatment, as well as for the development of novel drugs.
关键词:
缺血性脑卒中;二级预防;辨证论治;中医药;中医药优势病种
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This study was supported by the National Natural Science Foundation of China (No. 82174112), and the Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (No.22HHZYSS00015).
Hanyu Zhang a, b, Bowen Jin a, b, Xinyu You a, b, Pengrong Yi a, b, Hong Guo a, b, Lin Niu a, b, Qingsheng Yin a, b, Jiangwei Shi c, d, Yanjun Zhang c, d,*, Pengwei Zhuang a, b,*. Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke[J]. Chinese Herbal Medicines (CHM),2023,15(4):496-508
