Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice

doi:https://doi.org/10.1016/j.chmed.2023.05.003

Archive > Volume 15 Issue 4 > 2023,15(4):485-495. DOI:https://doi.org/10.1016/j.chmed.2023.05.003 Prev Next

中药治疗前列腺癌：从实验研究到临床实践

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Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice

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摘要:

前列腺癌是全球男性第二大常见恶性肿瘤，造成巨大的健康负担，已成为全球性健康问题。精准医疗为前列腺癌患者提供了更多的治疗选择，但其普及性、耐药性和不良反应仍需关注。中药作为一种恶性肿瘤的替代疗法，具有多靶点、多途径、低毒性等优势，已被广泛接受。我们检索了近五年发表在PubMed、Embase和Web of Science上的中药治疗前列腺癌的文献，类型包括基础实验研究和临床试验。我们发现了5种中草药配方和6种中药单体提取物，以及12种中草药衍生化合物可用来治疗前列腺癌，其作用机制包括诱导细胞凋亡、自噬和细胞周期停滞，抑制前列腺癌细胞的血管生成、增殖和迁移，逆转耐药性，以及增强免疫。其作用机制包括PI3K/Akt/mTOR、AR、EGFR和Wnt/β-catenin信号通路，这些通路通常与前列腺癌的发展有关。我们还总结了中草药在激素敏感型和去势抵抗型前列腺癌患者中的优势，并为其进一步的实验设计和临床应用提供了思路。

Abstract:

Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue, and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines (CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in PubMed, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance, and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR, EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application.

关键词:

中草药;临床试验;实验研究;前列腺癌;综述

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This work was supported by the National Administration of Traditional Chinese Medicine: 2019 Project of Building Evidence-based Practice Capacity for TCM (No. 2019XZZX-ZL007); National Administration of Traditional Chinese Medicine: Jia Yingjie National Famous Traditional Chinese Medicine Experts Academic Experience Inheritance Project (No. 974022).

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中药治疗前列腺癌：从实验研究到临床实践

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Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice

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