Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review
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摘要:
昆仙胶囊（KX）是中国传统中药，用于治疗类风湿关节炎、肾病综合征、系统性红斑狼疮、过敏性紫癜、强直性脊柱炎、银屑病关节炎和湿疹等。但目前关于昆仙胶囊的临床应用和不良反应缺乏全面系统的文献综述。因此，本文对PubMed、China National Knowledge Infrastructure和万方数据库报道的昆仙胶囊药理作用、临床应用及其不良反应的相关文献进行了较为详细的总结和论述。这些文献由两位作者独立收集，时间不限，文献截止日期为2022年11月30日。检索词包括昆仙胶囊及/或临床疗效、药理、疾病、治疗、不良反应和质量控制。昆仙胶囊已被证明可通过抑制炎症反应和诱导凋亡来有效治疗自身免疫性关节炎。研究表明昆仙胶囊具有抗炎和镇痛作用，可改善关节功能。昆仙胶囊具有祛风除湿，补肾通络的作用，可治疗多种疾病。但也有研究表明昆仙胶囊对多个系统具有副作用。综上所述，本文重点综述了昆仙胶囊在治疗或预防多种疾病中的应用，为深入研究和拓展其临床应用提供了新思路。
Abstract:
Kunxian Capsule (KX) is a popular Chinese patent medicine for the treatment of rheumatoid arthritis, nephrotic syndrome, systemic lupus erythematosus, Henoch-Sch?nlein purpura, ankylosing spondylitis, psoriatic arthritis and eczema. However, there is scarcity of comprehensive information on the significance of KX in the clinical application and its side effects. Hence, it is aimed to provide a review of the significance of KX, with a focus on the pharmacological effects, clinical applications, and its adverse reactions. This review was based on the published literatures in PubMed, China National Knowledge Infrastructure and WanFang database. The articles were collected by two independent authors with no time limits applied until November 30, 2022. The search term includes Kunxian Capsule and/or clinical effect, pharmacology, disease, therapy, adverse effects and quality control. KX has been shown to be effective in the treatment of autoimmune arthritis by inhibiting inflammatory responses and inducing apoptosis. Many studies suggest that KX has anti-inflammatory and analgesic properties that aid in the improvement of joint functions. KX dispels wind, removes dampness, invigorates the kidneys, and promotes blood circulation, thereby curing various diseases. However, studies also suggest KX-related adverse reactions in multiple systems. Overall, this review highlights the scientific basis of KX in curing or preventing various diseases and provides novel insights for further research and clinical applications.
关键词:
不良反应;自身免疫性疾病;草药;昆仙胶囊;类风湿性关节炎
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This study was supported by Taishan Scholars Program (tsqn202211204), National Key R&D Program of China (2018YFC1707300), Shandong Provincial Natural Science Foundation (ZR2020YQ60), Jinan Talent Project for University (2021GXRC047), Science, Education and Industry Integration Innovation Pilot Project of Qilu University of Technology (Shandong Academy of Sciences) (2022PYI016).
Ruijiao Ma a, b,, Maharajan Kannan a, b,, Kaiyan Zhuang a, b, Qing Xia a, b, Dong Sun c, Pengfei Tu d, Taiping Fan e, Kechun Liu a, b, Yun Zhang a, b,*. Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review[J]. Chinese Herbal Medicines (CHM),2023,15(2):222-230
