Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis

doi:https://doi.org/10.1016/j.chmed.2023.03.003

Archive > Volume 15 Issue 2 > 2023,15(2):181-200. DOI:https://doi.org/10.1016/j.chmed.2023.03.003 Prev Next

中药通过调节肠道菌群-肠道免疫轴治疗溃疡性结肠炎

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Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis

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摘要:

溃疡性结肠炎 (UC) 是一种高复发率的炎症性肠病。最近的研究表明，微生物生态失调和肠道免疫异常是UC中引发一系列炎症反应的关键因素。调节肠道微生物群-肠道免疫回路被认为是缓解UC的关键策略之一。据报道，许多中草药，包括一些单味草药、中药配方及其衍生成分，通过调节肠道微生物群和肠道免疫，对UC具有保护作用。一些临床试验结果令人欣喜。本文主要从调节肠道微生物群和肠道免疫等肠道稳态的机制方面对中药治疗UC的研究现状进行综述，并对已有的临床试验进行了总结。

Abstract:

Ulcerative colitis (UC) is one of types of inflammatory bowel disease with high recurrence. Recent studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a series of inflammatory responses in the UC. Modulating the gut microbiota-intestinal immunity loop has been suggested as one of key strategies for relieving UC. Many Chinese herbal medicines including some of single herb, herbal formulas and the derived constituents have been reported with protective effect against UC through modulating gut microbiome and intestinal immunity. Some clinical trials have shown promising results. This review thus focused on the current knowledge on using Chinese herbal medicines for treating UC from the mechanism aspects of regulating intestinal homeostasis involving microbiota and gut immunity. The existing clinical trials are also summarized.

关键词:

中草药;肠道微生物群;炎症;炎症性肠病;肠道免疫;溃疡性结肠炎

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This study was supported by the grants from the Sichuan Science and Technology Program, China (No. 2023NSFSC0614, 2022YFS0624), grant from Science and Technology Program of Luzhou, China (No. 21CGZHPT0001, 2022-YJY-127), grant from Southwest Medical University, China (No. 2021ZKZD017), and grant from The Open Research Project Program of the State Key Laboratory of Quality Research in Chinese Medicine (University of Macau), China (SKL-QRCM-OP21006).

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中药通过调节肠道菌群-肠道免疫轴治疗溃疡性结肠炎

Reviews

Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis

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