Cancer still has elevated morbidity and mortality, which undoubtedly impacts the life quality of affected individuals. Remarkable advances have been made in cancer therapy, although the toxicities of traditional therapies remain an obvious challenge. Dahuang Zhechong Pill (DHZCP), developed by Zhongjing Zhang in the Synopsis of the Golden Chamber, represents an effective anticancer traditional Chinese medicine (TCM). In this review, it was found that DHZCP is therapeutically utilized in liver, lung, gastric, pancreatic and other cancers in clinic. Pharmacological evidence showed that its anti-tumor mechanisms mainly involve induced cell cycle arrest, apoptosis and autophagy, as well as suppressed tumor cell proliferation, obstructed angiogenesis and metastasis, enhanced immunity, and reversal of multidrug resistance. The present review provides a solid basis for the clinical application of DHZCP and may promote the wide use of TCM in clinical antitumor application.
关键词:
抗肿瘤作用;大黄蛰虫丸;药理机制;传统中药
Keywords:
Project Supported:
This work was financially supported by National Science and Technology Major Projects (No. 2018ZX09201-011, 2018ZX09301-011-003), the National High Technology Research and Development Program of China (No. 2019YFC1711400).
Yingying Tian a,, Beibei Ma b,, Shangyue Yu a, Yilin Li a, Hailuan Pei a, Shiqiu Tian a, Xinyue Zhao a, Chuang Liu a, Zeping Zuo b,*, Zhibin Wang a, b,*. Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill[J]. Chinese Herbal Medicines (CHM),2023,15(2):169-180
