Emerging therapeutic role of Prunella vulgaris in thyroid disease
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摘要:
Abstract:
Thyroid disease is characterized by unusual levels of thyroid hormones, which results in either hyperthyroidism or hypothyroidism. The pathology of a particular type or stage of thyroid disease is very complicated, and always linked to a variety of biological functions. Although the mortality rate is not high, thyroid dysfunction could leads to metabolic and immunological disorders that can subsequently cause discomfort. To date, many medical drugs are suggested to have curative effects on thyroid disease, however, drug toxicity and long treatment periods encourage the search for more promising drugs. Prunella vulgaris L. (Labiatae) is a popular herb that has shown great potential for improving human immunity and organ protection. It has been extensively used in the treatment of many diseases but its ability to treat specific diseases has not been fully reported. In this review, a literature search regarding herbs and herbal recipes for treating thyroid disease were carried out, organized, and summarized. In addition, this study conducted a literature search on the current situation and progress of P. vulgaris treatment for various diseases. Finally, this study discussed studies regarding P. vulgaris treatment of goiter, and the mechanism of treatment through the regulation of apoptosis. Accordingly, a combination therapy of herbs and Western medicine can provide significant therapeutic effects in the clinical treatment of thyroid disease. Furthermore, the association between P. vulgaris and various diseases suggests that P. vulgaris is rich in a variety of active substances that can fight oxidation and participate in the regulation of apoptosis, thus having a protective effect on the thyroid. Here, a comprehensive literature review regarding the application of herbs or herbal recipes in the treatment of thyroid disease was presented. It is concluded that there is strong evidence for further research regarding the use of P. vulgaris in the treatment of thyroid diseases.
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We appreciated Tegexi Baiyin for giving useful information on ‘general physiologies of applying herbs to treat diseases’ for this manuscript. This work was financially supported by the Inner Mongolia Natural Science Foundation Project (2020MS08203) and the New drug Research & Development Projects of the Inner Mongolia Medical Research Institute (YJS20186 and 2016YJS21).
Wen Zhang a, c,, Qimuge Wuhan c,, Meiri Na b, Riba Hu b, Qier Mu b, Xilinqiqige Bao b, c,*. Emerging therapeutic role of Prunella vulgaris in thyroid disease[J]. Chinese Herbal Medicines (CHM),2022,14(3):
