Immunomodulatory activity of polysaccharides from Brassica rapa by activating Akt/NF-κB signaling
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
摘要:
Abstract:
Objective: To investigate the immunomodulatory activity of polysaccharides from the roots of Brassica rapa. Methods: The crude polysaccharide from roots of B. rapa (BRP) was extracted and purified to further investigate the active fraction of BRT for inducing macrophage phagocytosis. Results: Effects on RAW264.7 cells demonstrated that BRP behaved better phagocytic capacity and had potent immunomodulatory activity, including increasing production of nitric oxide (NO), tumor necrosis factor α (TNFα) and upregulating mRNA levels of inducible NO synthase (iNOS) and TNFα. Furthermore, modulation of macrophage by BRP was indicated to be mediated via the activation of Akt and nuclear factor-kappa B (NF-κB). Conclusion: The beneficial effects of BRP could be used as an immunotherapeutic adjuvant in treatment of inflammatory diseases.
关键词:
Keywords:
Project Supported:
This research was supported by grants from the Natural Science Foundation of China (81760778), the Fundamental Research Funds for Public-interest Scientific Institution in Xinjiang Uygur Autonomous Region (KYGY2016169), and CAMS Innovation Fund for Medical Sciences (2017-I2M-1-012).
Wei-wei Guo a, Qian-xiao Zhang b, c, Yu Du a, b, Jun-ting Guoa, b, Ting-ting Zhao b, Li-ping Bai a, b, Xi-qiang An b. Immunomodulatory activity of polysaccharides from Brassica rapa by activating Akt/NF-κB signaling[J]. Chinese Herbal Medicines (CHM),2022,14(1):90-96
