A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
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摘要:
Abstract:
Objective: To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition (SCMC) ointment on the rabbit ear hypertrophic scar models. Methods: The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests. The SCMC ointment was prepared through emulsifying method. The rabbit ear hypertrophic scar models were established and used to investigate the anti-hypertrophic scar effect of SCMC ointment. Results: Our results demonstrated that all the quality control indications of the SCMC ointment met the requirements. Anti-hypertrophic scar activity results showed that all the rabbit ear scar tissues appeared different degrees of shrink and fading, and took an unobvious but palpable shift from hard to soft texture with the low, middle and high concentration SCMC ointments treatments in vivo. Additionally, on 21st day the scar area and thickness in different concentrations of SCMC ointment groups were significantly reduced than control group, in a concentration-dependent manner. The immunohistochemical results also indicated that the SCMC ointment had good anti-hypertrophic scar properties and could inhibit hypertrophic scar formation. Conclusion: The SCMC ointment could improve the blood circulation condition of hypertrophic scar tissues. Our research has demonstrated the Chinese medicine composition ointment with good anti-hypertrophic scar properties that could be used to treat hypertrophic scars. Meanwhile, it provides a theoretical basis for further clinical application.
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The research was supported by grants from Academic Talent Project of Guizhou Provincial Department of Science and Technology (Qiankehe Platform Talent [2017]5735-28), the Doctorial Start-up Foundation of Guizhou University of Traditional Chinese Medicine (2016-3043-043160011), Guizhou discipline construction project (GNYL[2017]008), the National Key Research and Development Program of China (2018YFC1708100), University Students Chinese Medicine Preparation Innovation and Entrepreneurship Studio (Qiangaojiaofa [2017]158), Program for University Students Innovation and Entrepreneurship Plan of Guizhou University of Traditional Chinese Medicine (GZY Dachuanghe (2018) 30), Guizhou Province Top Major Chinese Medicine (Qianjiaogaofa [2017]158) and Guizhou High-Level Innovative Talents Training Program (Qiankehe [2015] 4032).
Zu-hua Wang, Xue-yan Sun, Jiao-jiao Zhang, Francesca Giampieri, Cheng-ju Jiang, Ting-ting Feng, Zhi-wei Wang, Rong-yi Chen, Maurizio Battino, Ying Zhou. A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars[J]. Chinese Herbal Medicines (CHM),2021,13(2):210-220
